CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008197
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein numb homolog 
Protein Synonyms/Alias
 h-Numb; Protein S171 
Gene Name
 NUMB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
73KAERKFFKGFFGKTGubiquitination[1]
286GFPALSQKMSPFKRQubiquitination[2, 3]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. 
Sequence Annotation
 DOMAIN 33 193 PID.
 MOD_RES 244 244 Phosphoserine.
 MOD_RES 276 276 Phosphoserine; by CaMK1 (By similarity).
 MOD_RES 295 295 Phosphoserine; by CaMK1 (By similarity).
 MOD_RES 631 631 Phosphothreonine (By similarity).
 MOD_RES 634 634 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 651 AA 
Protein Sequence
MNKLRQSFRR KKDVYVPEAS RPHQWQTDEE GVRTGKCSFP VKYLGHVEVD ESRGMHICED 60
AVKRLKAERK FFKGFFGKTG KKAVKAVLWV SADGLRVVDE KTKDLIVDQT IEKVSFCAPD 120
RNFDRAFSYI CRDGTTRRWI CHCFMAVKDT GERLSHAVGC AFAACLERKQ KREKECGVTA 180
TFDASRTTFT REGSFRVTTA TEQAEREEIM KQMQDAKKAE TDKIVVGSSV APGNTAPSPS 240
SPTSPTSDAT TSLEMNNPHA IPRRHAPIEQ LARQGSFRGF PALSQKMSPF KRQLSLRINE 300
LPSTMQRKTD FPIKNAVPEV EGEAESISSL CSQITNAFST PEDPFSSAPM TKPVTVVAPQ 360
SPTFQANGTD SAFHVLAKPA HTALAPVAMP VRETNPWAHA PDAANKEIAA TCSGTEWGQS 420
SGAASPGLFQ AGHRRTPSEA DRWLEEVSKS VRAQQPQASA APLQPVLQPP PPTAISQPAS 480
PFQGNAFLTS QPVPVGVVPA LQPAFVPAQS YPVANGMPYP APNVPVVGIT PSQMVANVFG 540
TAGHPQAAHP HQSPSLVRQQ TFPHYEASSA TTSPFFKPPA QHLNGSAAFN GVDDGRLASA 600
DRHTEVPTGT CPVDPFEAQW AALENKSKQR TNPSPTNPFS SDLQKTFEIE L 651 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0034332; P:adherens junction organization; IEA:Compara.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0021670; P:lateral ventricle development; ISS:UniProtKB.
 GO:0060487; P:lung epithelial cell differentiation; IEA:Compara.
 GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Compara.
 GO:0021849; P:neuroblast division in subventricular zone; ISS:UniProtKB.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0050769; P:positive regulation of neurogenesis; ISS:UniProtKB.
 GO:0030862; P:positive regulation of polarized epithelial cell differentiation; IEA:Compara. 
Interpro
 IPR016698; Numb/numb-like.
 IPR010449; Numb_domain.
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom. 
Pfam
 PF06311; NumbF
 PF00640; PID 
SMART
 SM00462; PTB 
PROSITE
 PS01179; PID 
PRINTS