| Tag | Content |
|---|
| CPLM ID | CPLM-016078 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Junctophilin-4 |
Protein Synonyms/Alias | JP-4; Junctophilin-like 1 protein |
Gene Name | Jph4 |
Gene Synonyms/Alias | Jphl1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 401 | AASSVAEKAVEAARM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. |
Sequence Annotation | REPEAT 15 37 MORN 1.
REPEAT 39 60 MORN 2.
REPEAT 61 82 MORN 3.
REPEAT 83 105 MORN 4.
REPEAT 106 128 MORN 5.
REPEAT 129 151 MORN 6.
REPEAT 282 304 MORN 7.
REPEAT 305 327 MORN 8. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 628 AA |
Protein Sequence | MSPGGKFDFD DGGCYVGGWE AGRAHGYGVC TGPGAQGEYS GCWAHGFESL GVFTGPGGHS 60
YQGHWQQGKR EGLGVERKSR WTYRGEWLGG LKGRSGVWES VSGLRYAGLW KDGFQDGYGT 120
ETYSDGGTYQ GQWQAGKRHG YGVRQSVPYH QAALLRSPRR TSLDSGHSDP PTPPPPLPLP 180
GDEGGSPASG SRGGFVLAGP GDADGASSRK RTPAAGGFFR RSLLLSGLRA GGRRSSLGSK 240
RGSLRSEVSS EVGSTGPPGS EASGPPIPAP PALIEGSATE VYAGEWRADR RSGYGVSQRS 300
NGLRYEGEWL GNRRHGYGRT TRPDGSREEG KYKRNRLVHG GRVRSLLPLA LRRGKVKEKV 360
DRAVEGARRA VSAARQRQEI AAARAADALL KAVAASSVAE KAVEAARMAK LIAQDLQPML 420
EAPGRRPRQD SGGSDTEPLD EDSPGVYENG LTPSEGSPEL PSSPASSHQP WRAPACRSPL 480
PPGGNWGPFS SPKAWPEEWG GPGEQAEELA GYEAEDEAGV QGPGPRDGSP LLGGCSDSSG 540
SLREEEGEDE ESLPQLRAPG GSESEPVTTP VLRGLSSRGP DAGCLTEEVE EPAPTERPAQ 600
PGAANPLVVG AVALLDLSLA FLFSQLLT 628 |
Gene Ontology | GO:0043198; C:dendritic shaft; IDA:MGI. GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005790; C:smooth endoplasmic reticulum; IDA:MGI. GO:0007612; P:learning; IGI:MGI. GO:0050885; P:neuromuscular process controlling balance; IGI:MGI. GO:0048167; P:regulation of synaptic plasticity; IGI:MGI. |
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PROSITE | |
PRINTS | |