CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044695
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myotubularin-related protein 4 
Protein Synonyms/Alias
  
Gene Name
 MTMR4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
184SHINSNYKLCPSYPQubiquitination[1]
202VPVWITDKELENVASubiquitination[1]
257YLVTSIAKACALDPGubiquitination[1, 2]
825LENPRFGKMPLELVRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1138 AA 
Protein Sequence
MGEEGPPSLE YIQAKDLFPP KELVKEEENL QVPFTVLQGE GVEFLGRAAD ALIAISNYRL 60
HIKFKDSVIN VPLRMIDSVE SRDMFQLHIS CKDSKVVRCH FSTFKQCQEW LSRLSRATAR 120
PAKPEDLFAF AYHAWCLGLT EEDQHTHLCQ PGEHIRCRQE AELARMGFDL QNVWRVSHIN 180
SNYKLCPSYP QKLLVPVWIT DKELENVASF RSWKRIPVVV YRHLRNGAAI ARCSQPEISW 240
WGWRNADDEY LVTSIAKACA LDPGTRATGG SLSTGNNDTS EACDADFDSS LTACSGVEST 300
AAPQKLLILD ARSYTAAVAN RAKGGGCECE EYYPNCEVVF MGMANIHAIR NSFQYLRAVC 360
SQMPDPSNWL SALESTKWLQ HLSVMLKAAV LVANTVDREG RPVLVHCSDG WDRTPQIVAL 420
AKILLDPYYR TLEGFQVLVE SDWLDFGHKF GDRCGHQENV EDQNEQCPVF LQWLDSVHQL 480
LKQFPCLFEF NEAFLVLHPV CHVRALHLWT AVYLPASSPC TLGEENMDLY LSPVAQSQEF 540
SGRSLDRLPK TRSMDDLLSA CDTSSPLTRT SSDPNLNNHC QEVRVGLEPW HSNPEGSETS 600
FVDSGVGGPQ QTVGEVGLPP PLPSSQKDYL SNKPFKSHKS CSPSYKLLNT AVPREMKSNT 660
SDPEIKVLEE TKGPAPDPSA QDELGRTLDG IGEPPEHCPE TEAVSALSKV ISNKCDGVCN 720
FPESSQNSPT GTPQQAQPDS MLGVPSKCVL DHSLSTVCNP PSAACQTPLD PSTDFLNQDP 780
SGSVASISHQ EQLSSVPDLT HGEEDIGKRG NNRNGQLLEN PRFGKMPLEL VRKPISQSQI 840
SEFSFLGSNW DSFQGMVTSF PSGEATPRRL LSYGCCSKRP NSKQMRATGP CFGGQWAQRE 900
GVKSPVCSSH SNGHCTGPGG KNQMWLSSHP KQVSSTKPVP LNCPSPVPPL YLDDDGLPFP 960
TDVIQHRLRQ IEAGYKQEVE QLRRQVRELQ MRLDIRHCCA PPAEPPMDYE DDFTCLKESD 1020
GSDTEDFGSD HSEDCLSEAS WEPVDKKETE VTRWVPDHMA SHCYNCDCEF WLAKRRHHCR 1080
NCGNVFCAGC CHLKLPIPDQ QLYDPVLVCN SCYEHIQVSR ARELMSQQLK KPIATASS 1138 
Gene Ontology
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR010569; Myotub-related.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF01363; FYVE
 PF06602; Myotub-related 
SMART
 SM00064; FYVE 
PROSITE
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50178; ZF_FYVE 
PRINTS