CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031296
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ56039, highly similar to 5-aminolevulinate synthase, nonspecific, mitochondrial (EC 2.3.1.37) 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
556VRVADAAKNTEVCDEubiquitination[1]
651SYFSGLSKLVSAQA*ubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Pyridoxal phosphate. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 657 AA 
Protein Sequence
MDEWLLLHLD EPAYFLNMES VVRRCPFLSR VPQAFLQKAG KSLLFYAQNC PKMMEVGAKP 60
APRALSTAAV HYQQIKETPP ASEKDKTAKA KVQQTPDGSQ QSPDGTQLPS GHPLPATSQG 120
TASKCPFLAA QMNQRGSSVF CKASLELQED VQEMNAVRKE VAETSAGPSV VSVKTDGGDP 180
SGLLKNFQDI MQKQRPERVS HLLQDNLPKS VSTFQYGRFF EKKIDEKKND HTYRVFKTVN 240
RRAHIFPMAD DYSDSLITKK QVSVWCSNDY LGMSRHPRVC GAVMDTLKQH GAGAGGTRNI 300
SGTSKFHVDL ERELADLHGK DAALLFSSCF VANDSTLFTL AKMMPGCEIY SDSGNHASMI 360
QGIRNSRVPK YIFRHNDVSH LRELLQRSDP SVPKIVAFET VHSMDGAVCP LEELCDVAHE 420
FGAITFVDEV HAVGLYGARG GGIGDRDGVM PKMDIISGTL GKAFGCVGGY IASTSSLIDT 480
VRSYAAGFIF TTSLPPMLLA GALESVRILK SAEGRVLRRQ HQRNVKLMRQ MLMDAGLPVV 540
HCPSHIIPVR VADAAKNTEV CDELMSRHNI YVQAINYPTV PRGEELLRIA PTPHHTPQMM 600
NYFLENLLVT WKQVGLELKP HSSAECNFCR RPLHFEVMSE REKSYFSGLS KLVSAQA 657 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:InterPro.
 GO:0003870; F:5-aminolevulinate synthase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006778; P:porphyrin-containing compound metabolic process; IEA:InterPro.
 GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro. 
Interpro
 IPR010961; 4pyrrol_synth_NH2levulA_synth.
 IPR015118; 5aminolev_synth_preseq.
 IPR001917; Aminotrans_II_pyridoxalP_BS.
 IPR004839; Aminotransferase_I/II.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00155; Aminotran_1_2
 PF09029; Preseq_ALAS 
SMART
  
PROSITE
 PS00599; AA_TRANSFER_CLASS_2 
PRINTS