CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011932
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate receptor ionotropic, NMDA 2A 
Protein Synonyms/Alias
 GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A 
Gene Name
 GRIN2A 
Gene Synonyms/Alias
 NMDAR2A 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
938IMDMVSDKGNLMYSDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. 
Sequence Annotation
 REGION 511 513 Glutamate binding (By similarity).
 REGION 689 690 Glutamate binding (By similarity).
 MOTIF 1462 1464 PDZ-binding.
 METAL 128 128 Zinc (By similarity).
 METAL 283 283 Zinc (By similarity).
 BINDING 518 518 Glutamate (By similarity).
 BINDING 731 731 Glutamate; via amide nitrogen (By
 MOD_RES 888 888 Phosphothreonine (By similarity).
 MOD_RES 917 917 Phosphoserine (By similarity).
 MOD_RES 929 929 Phosphoserine (By similarity).
 MOD_RES 943 943 Phosphotyrosine (By similarity).
 MOD_RES 1025 1025 Phosphoserine (By similarity).
 MOD_RES 1459 1459 Phosphoserine (By similarity).
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 340 340 N-linked (GlcNAc...) (Potential).
 CARBOHYD 380 380 N-linked (GlcNAc...) (Potential).
 CARBOHYD 443 443 N-linked (GlcNAc...) (Potential).
 CARBOHYD 444 444 N-linked (GlcNAc...) (Potential).
 CARBOHYD 541 541 N-linked (GlcNAc...) (Potential).
 DISULFID 87 320 By similarity.  
Keyword
 3D-structure; Alternative splicing; Calcium; Cell junction; Cell membrane; Chromosomal rearrangement; Complete proteome; Disease mutation; Disulfide bond; Epilepsy; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Magnesium; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1464 AA 
Protein Sequence
MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE LRTLWGPEQA 60
AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSHT 120
FVPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY 180
REFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL 240
SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT 300
TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR 360
LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE 420
DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV 480
TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS 540
NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT 600
IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD 660
QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL 720
KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL 780
QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL 840
FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS 900
AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ GKESIFGDNM 960
NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKANSRP RQLWKKSVDS 1020
IRQDSLSQNP VSQRDEATAE NRTHSLKSPR YLPEEMAHSD ISETSNRATC HREPDNSKNH 1080
KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT 1140
LPENVDFPDP YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH 1200
SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGNP 1260
ATGEQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR ELDLSRPSRS ISLKDRERLL 1320
EGNFYGSLFS VPSSKLSGKK SSLFPQGLED SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG 1380
RCPSDPYKHS LPSQAVNDSY LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS 1440
TPRVLNSCSN RRVYKKMPSI ESDV 1464 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; ISS:BHF-UCL.
 GO:0017146; C:N-methyl-D-aspartate selective glutamate receptor complex; IDA:UniProtKB.
 GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; IEA:Compara.
 GO:0005262; F:calcium channel activity; IEA:Compara.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0004972; F:N-methyl-D-aspartate selective glutamate receptor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; ISS:UniProtKB.
 GO:0033058; P:directional locomotion; IEA:Compara.
 GO:0042417; P:dopamine metabolic process; IEA:Compara.
 GO:0007611; P:learning or memory; TAS:ProtInc.
 GO:0007613; P:memory; IEA:Compara.
 GO:0042177; P:negative regulation of protein catabolic process; IEA:Compara.
 GO:0022008; P:neurogenesis; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0051930; P:regulation of sensory perception of pain; IEA:Compara.
 GO:0048167; P:regulation of synaptic plasticity; IEA:Compara.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IDA:UniProtKB.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0019233; P:sensory perception of pain; IEA:Compara.
 GO:0042428; P:serotonin metabolic process; IEA:Compara.
 GO:0030431; P:sleep; IEA:Compara.
 GO:0001964; P:startle response; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome.
 GO:0008542; P:visual learning; IEA:Compara. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt.
 IPR018884; NMDAR2_C.
 IPR001638; SBP_bac_3. 
Pfam
 PF01094; ANF_receptor
 PF00060; Lig_chan
 PF10565; NMDAR2_C
 PF00497; SBP_bac_3 
SMART
 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 
PROSITE
  
PRINTS
 PR00177; NMDARECEPTOR.