UniProt Accession

 QCR1_MOUSE; Q9CZ13; Q3TV75; Q9CWL6 

Genbank Protein ID

 AK013128; AK010553; AK151764; AK160337; CH466560 

Genbank Nucleotide ID

 BAB28666.1; BAB27022.1; BAE30670.1; BAE35744.1; EDL21324.1 

Protein Name

 Cytochrome b-c1 complex subunit 1, mitochondrial 

Protein Synonyms/Alias

 Complex III subunit 1; Core protein I; Ubiquinol-cytochrome-c reductase complex core protein 1 

Gene Name

 Uqcrc1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
85	GSRYETEKNNGAGYF	acetylation	[1, 2, 3, 4]
99	FLEHLAFKGTKNRPG	acetylation	[2]
111	RPGNALEKEVESIGA	acetylation	[2, 3, 4]
134	EHTAYLIKALSKDLP	acetylation	[2]
138	YLIKALSKDLPKVVE	acetylation	[2, 3, 4, 5, 6, 7]
138	YLIKALSKDLPKVVE	succinylation	[7]
142	ALSKDLPKVVELLAD	acetylation	[6]
163	LEDSQIEKERDVILR	acetylation	[1, 3, 6, 7]
163	LEDSQIEKERDVILR	succinylation	[7]
248	QLLDLAQKHLSSVSR	acetylation	[1, 3, 4, 5, 6, 8]
248	QLLDLAQKHLSSVSR	ubiquitination	[9]
447	MLRDICSKYFYDQCP	acetylation	[4, 6]

Reference

 [1] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [6] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [7] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [8] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [9] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity). 

Sequence Annotation

 MOD_RES 111 111 N6-acetyllysine (By similarity).
 MOD_RES 138 138 N6-acetyllysine.
 MOD_RES 248 248 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 480 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005750; C:mitochondrial respiratory chain complex III; IEA:Compara.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IDA:MGI.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0043279; P:response to alkaloid; IEA:Compara. 

Interpro

 IPR011249; Metalloenz_LuxS/M16.
 IPR011237; Pept_M16_dom.
 IPR011765; Pept_M16_N.
 IPR007863; Peptidase_M16_C. 

Pfam

 PF00675; Peptidase_M16
 PF05193; Peptidase_M16_C 

SMART

  

PROSITE

 PS00143; INSULINASE 

PRINTS