CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041776
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Huntingtin 
Protein Synonyms/Alias
 Huntington disease gene homolog 
Gene Name
 Htt 
Gene Synonyms/Alias
 Hdh; rCG_36155 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
154LELYKEIKKNGAPRSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3120 AA 
Protein Sequence
MATLEKLMKA FESLKSFQQQ QQQQQPPPQA PPPPPPPPPQ PPQPPPQGQP PPPPPLPGPA 60
EEPLHRPKKE LSATKKDRVN HCLTICENIV AQSLRNSPEF QKLLGIAMEL FLLCSDDAES 120
DVRMVADECL NKVIKALMDS NLPRLQLELY KEIKKNGAPR SLRAALWRFA ELAHLVRPQK 180
CRPYLVNLLP CLTRTSKRPE ESVQETLAAA VPKIMASFGN FANDNEIKVL LKAFIANLKS 240
SSPTVRRTAA GSAVSICQHS RRTQYFYNWL LNVLLGLLVP MEEDHPTLLI LGVLLTLRCL 300
VPLLQQQVKD TSLKGSFGVT RKEMEVSPSA EQLVQVYELT LHHTQHQDHN VVTGALELLQ 360
QLFRTPPPEL LQALTTPGGL GQLTLVREEA GGRGRSGSIV ELLAGGGSSC SPVLSRKQKG 420
KVLLGEEEAL EDDSESRSDV SSSAFAASVK SEIGGELAAS SSGVSTPGSV GHDIITEQPR 480
SQHTLQADSV DLSGCDLTSA ATDGDEEDIL SHSSSQFSAV PSDPAMDLND GTQASSPISD 540
SSQTTTEGPD SAVTPSDSSE IVLDGADSQY LGVQIGQPQE EDEEEAAGVL SGEVSDVFRN 600
SSLALQQAHL LERMGHSRQP SDSSVDKFVS KDEVAEAGDP ESKPCRIKGD IGQPNDDDSA 660
PLVHCVRLLS ASFLLTGEKK ALVPDRDVRV SVKALALSCI GAAVALHPES FFSKLYKVPL 720
STMESTEEQY VSDILNYIDH GDPQVRGATA ILCGTLVYSI LSRSRLRVGD WLGTIRALTG 780
NTFSLVDCIP LLQKTLKDES SVTCKLACTA VRHCVLSLCS SSYSDLGLQL LIDMLPLKNS 840
SYWLVRTELL ETLAEIDFRL VSFLEAKAES LHRGAHHYTG FLKLQERVLN NVVIYLLGDE 900
DPRVRHVAAT TLTRLVPKLF YKCDQGQADP VVAVARDQSS VYLKLLMHET QPPSHFSVST 960
ITRIYRGYSL LPSVTDVTME NNLSRVVAAV SHELITSTTR ALTFGCCEAL CVLSAAFPVC 1020
TWSLGWHCGV PPLSASDESR KSCTVGMASM ILTLLSSAWF PLDLSAHQDA LILAGNLLAA 1080
SAPKSLRSSW ASEEEGSSAA TRQEEIWPAL GDRTLVPMVE QLFSHLLKVI NICAHVLDDV 1140
TPGPAIKAAL PSLTNPPSLS PIRRKGKEKE PGEQTSTPMS PKKGGEASTA SRQSDTSGPV 1200
TASKSSSLGS FYHLPSYLRL HDVLKATHAN YKVTLDLQNS TEKFGGFLRS ALDVLSQILE 1260
LATLQDIGKC VEEVLGYLKS CFSREPMMAT VCVQQLLKTL FGTNLASQFD GLSSNPSKSQ 1320
CRAQRLGSSS VRPGLYHYCF MAPYTHFTQA LADASLRNMV QADQEHDASG WFDVLQKVSA 1380
QLKTNLTSVT KNRADKNAIH NHIRLFEPLV IKALKQYTTT TSVQLQKQVL DLLAQLVQLR 1440
VNYCLLDSDQ VFIGFVLKQF EYIEVGQFRE SEAIIPNIFF FLVLLSYERY HSKQIIGIPK 1500
IIQLCDGIMA SGRKAVTHAI PALQPIVHDL FVLRGTNKAD AGKELETQKE VVVSMLLRLI 1560
QYHQVLEMFI LVLQQCHKEN EDKWKRLSRQ VADIILPMLA KQQMHIDSHE ALGVLNTLFE 1620
ILAPSSLRPV DMLLRSMFIT PSTMASVSTV QLWISGILAI LRVLISQSTE DIVLSRIQEL 1680
SFSPYLISCP VINRLRDGDS NPTLGERSEG KQVKNLPEDT FSRFLLQLVG ILLEDIVTKQ 1740
LKVDMSEQQH TFYCQELGTL LMCLIHIFKS GMFRRITAAA TRLFTSDGCE GSFYTLDSLN 1800
ARVRAMVPTH PALVLLWCQI LLLINHTDHR WWAEVQQTPK RHSLSCTKSL NPQISAEEDS 1860
GSAAQLGMCN REIVRRGALI LFCDYVCQNL HDSEHLTWLI VNHIQDLISL SHEPPVQDFI 1920
SAIHRNSAAS GLFIQAIQSR CENLSTPTTL KKTLQCLEGI HLSQSGAVLT LYVDRLLGTP 1980
FRALARMVDT LACRRVEMLL AANLQSSMAQ LPEEELNRIQ EHLQNTGLAQ RHQRLYSLLD 2040
RFRLSTVQDS LSPLPPVTSH PLDGDGHTSL ETVNPDKDWY LQLVRSQCWT RSDSALLEGA 2100
ELVNRIPAED MSDFMMSSEF NLSLLAPCLS LGMSEIANGQ KSPLFEAARR VTLDRVTNVV 2160
QQLPAVHQVF QPFLPTEPTA YWSKLNDLFG DTTSYQSLTT LARALAQYLV VLSKVPAPLH 2220
LPPEKEGHTV KFVVMTLEAL SWHLIHEQIP LSLDLQAGLD CCCLALQVPG LWGVLSSPEY 2280
VTHTCSLIHC VRFILEAIAV QPGDQLLGPE SRSHTPRAVR KEEVDSDIQN LSHITSACEM 2340
VADMVESLQS VLALGHKRNS TLPSFLTAVL KNIVVSLARL PLVNSYTRVP PLVWKLGWSP 2400
KPGGDFGTVF PEIPVEFLQE KEVLKEFIYR INTLGWTSRT QFEETWATLL GVLVTQPLVM 2460
EQEESPPEED TERTQIHVLA VQAITSLVLS AMAVPVAGNP AVSCLEQQPR NKPLKALDTR 2520
FGRKLSMIRG IVEQEIQEMV SQRENTATHH SHQAWDPVPS LLPATTGALI SHDKLLLQIN 2580
SEREPGNMSY KLGQVSIHSV WLGNNITPLR EEEWDEEEEE EADAPAPTSP PVSPVNSRKH 2640
RAGVDIHSCS QFLLELYSRW ILPSSAARRT PVILISEVVR SLLVVSDLFT ERTQFEMMYL 2700
TLTELRRVHP SEDEILIQYL VPATCKAAAV LGMDKTVAEP VSRLLESTLR STHLPSQIGA 2760
LHGILYVLEC DLLDDTVKQL IPVVSDYLLS NLKGIAHCVN IHSQQHVLVM CATAFYLMEN 2820
YPLDVGPEFS ASVIQMCGVM LSGSEESTPS IIYHCALRGL ERLLLSEQLS RLDTESLVKL 2880
SVDRVNVQSP HRAMAALGLM LTCMYTGKEK ASPGRASDPS PATPDSESVI VAMERVSVLF 2940
DRIRKGFPCE ARVVARILPQ FLDDFFPPQD VMNKVIGEFL SNQQPYPQFM ATVVYKVFQT 3000
LHSAGQSSMV RDWVMLSLSN FTQRTPVAMA MWSLSCFLVS ASTSPWVSAI LPHVISRMGK 3060
LEQVDVNLFC LVATDFYRHQ IEEEFDRRAF QSVFEVVAAP GSPYHRLLAC LQNVHKVTAC 3120 
Gene Ontology
 GO:0005776; C:autophagic vacuole; IEA:Compara.
 GO:0030424; C:axon; IEA:Compara.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016234; C:inclusion body; IEA:Compara.
 GO:0005770; C:late endosome; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0050809; F:diazepam binding; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0008088; P:axon cargo transport; IEA:Compara.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0000052; P:citrulline metabolic process; IEA:Compara.
 GO:0008340; P:determination of adult lifespan; IEA:Compara.
 GO:0007212; P:dopamine receptor signaling pathway; IEA:Compara.
 GO:0007029; P:endoplasmic reticulum organization; IEA:Compara.
 GO:0016197; P:endosomal transport; IEA:Compara.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IEA:Compara.
 GO:0000132; P:establishment of mitotic spindle orientation; IEA:Compara.
 GO:0007030; P:Golgi organization; IEA:Compara.
 GO:0042445; P:hormone metabolic process; IEA:Compara.
 GO:0030073; P:insulin secretion; IEA:Compara.
 GO:0055072; P:iron ion homeostasis; IEA:Compara.
 GO:0051938; P:L-glutamate import; IEA:Compara.
 GO:0019244; P:lactate biosynthetic process from pyruvate; IEA:Compara.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara.
 GO:0021990; P:neural plate formation; IEA:Compara.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0021988; P:olfactory lobe development; IEA:Compara.
 GO:0048341; P:paraxial mesoderm formation; IEA:Compara.
 GO:0006606; P:protein import into nucleus; IEA:Compara.
 GO:0019805; P:quinolinate biosynthetic process; IEA:Compara.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Compara.
 GO:0034047; P:regulation of protein phosphatase type 2A activity; IEA:Compara.
 GO:0048167; P:regulation of synaptic plasticity; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:Compara.
 GO:0035176; P:social behavior; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0021756; P:striatum development; IEA:Compara.
 GO:0000050; P:urea cycle; IEA:Compara.
 GO:0047496; P:vesicle transport along microtubule; IEA:Compara.
 GO:0008542; P:visual learning; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000091; Huntingtin.
 IPR024613; Huntingtin_middle-repeat. 
Pfam
 PF12372; DUF3652 
SMART
  
PROSITE
  
PRINTS
 PR00375; HUNTINGTIN.