CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037201
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Putative Polycomb group protein ASXL2 
Protein Synonyms/Alias
  
Gene Name
 ASXL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
337QEIEKEKKVEPWKEQubiquitination[1, 2, 3, 4]
342EKKVEPWKEQFFESYubiquitination[1, 2, 3, 4, 5, 6, 7, 8]
1217NEQTTLSKENYLFTRubiquitination[1, 6, 8]
1231RGQTFDEKTLARDLIubiquitination[6, 8]
1243DLIQAAQKQMAHAVRubiquitination[6]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [8] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1407 AA 
Protein Sequence
MSHKEILQVI QREGLKEISS GTSPLACLNA MLHTNSRGEE GIFYKVPGRM GVYTLKKDVP 60
DGVKELSEGS EESSDGQSDS QSSENSSSSS DGGSNKEGKK SRWKRKVSSS SPQSGCPSPT 120
IPAGKVISPS QKHSKKALKQ ALKQQQQKKQ QQQCRPSISI SSNQHLSLKT VKAASDSVPA 180
KPATWEGKQS DGQTGSPQNS NSSFSSSVKV ENTLLGLGKK SFQRSERLHT RQMKRTKCAD 240
IDVETPDSIL VNTNLRALIN KHTFSVLPGD CQQRLLLLLP EVDRQVGPDG LMKLNGSALN 300
NEFFTSAAQG WKERLSEGEF TPEMQVRIRQ EIEKEKKVEP WKEQFFESYY GQSSGLSLED 360
SKKLTASPSD PKVKKTPAEQ PKSMPVSEAS LIRIVPVVSQ SECKEEALQM SSPGRKEECE 420
SQGEVQPNFS TSSEPLLSSA LNTHELSSIL PIKCPKDEDL LEQKPVTSAE QESEKNHLTT 480
ASNYNKSESQ ESLVTSPSKP KSPGVEKPIV KPTAGAGPQE TNMKEPLATL VDQSPESLKR 540
KSSLTQEEAP VSWEKRPRVT ENRQHQQPFQ VSPQPFLNRG DRIQVRKVPP LKIPVSRISP 600
MPFHPSQVSP RARFPVSITS PNRTGARTLA DIKAKAQLVK AQRAAAAAAA AAAAAASVGG 660
TIPGPGPGGG QGPGEGGEGQ TARGGSPGSD RVSETGKGPT LELAGTGSRG GTRELLPCGP 720
ETQPQSETKT TPSQAQPHSV SGAQLQQTPP VPPTPAVSGA CTSVPSPAHI EKLDNEKLNP 780
TRATATVASV SHPQGPSSCR QEKAPSPTGP ALISGASPVH CAADGTVELK AGPSKNIPNP 840
SASSKTDASV PVAVTPSPLT SLLTTATLEK LPVPQVSATT APAGSAPPSS TLPAASSLKT 900
PGTSLNMNGP TLRPTSSIPA NNPLVTQLLQ GKDVPMEQIL PKPLTKVEMK TVPLTAKEER 960
GMGALIATNT TENSTREEVN ERQSHPATQQ QLGKTLQSKQ LPQVPRPLQL FSAKELRDSS 1020
IDTHQYHEGL SKATQDQILQ TLIQRVRRQN LLSVVPPSQF NFAHSGFQLE DISTSQRFML 1080
GFAGRRTSKP AMAGHYLLNI STYGRGSESF RRTHSVNPED RFCLSSPTEA LKMGYTDCKN 1140
ATGESSSSKE DDTDEESTGD EQESVTVKEE PQVSQSAGKG DTSSGPHSRE TLSTSDCLAS 1200
KNVKAEIPLN EQTTLSKENY LFTRGQTFDE KTLARDLIQA AQKQMAHAVR GKAIRSSPEL 1260
FSSTVLPLPA DSPTHQPLLL PPLQTPKLYG SPTQIGPSYR GMINVSTSSD MDHNSAVPGS 1320
QVSSNVGDVM SFSVTVTTIP ASQAMNPSSH GQTIPVQAFS EENSIEGTPS KCYCRLKAMI 1380
MCKGCGAFCH DDCIGPSKLC VSCLVVR 1407 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR026905; ASX-like_PHD.
 IPR024811; ASX/ASX-like.
 IPR024817; ASXL2. 
Pfam
 PF13922; PHD_3 
SMART
  
PROSITE
  
PRINTS