UniProt Accession

 PRG4_MOUSE; Q9JM99; Q3UEL1; Q3V198 

Genbank Protein ID

 AB034730; AK132597; AK149469 

Genbank Nucleotide ID

 BAA92310.1; BAE21253.1; BAE28900.1 

Protein Name

 Proteoglycan 4 

Protein Synonyms/Alias

 Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan; Proteoglycan 4 C-terminal part 

Gene Name

 Prg4 

Gene Synonyms/Alias

 Msf; Szp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
412	EPPPTTKKPEPTTPK	acetylation	[1]
419	KPEPTTPKEPGPTTP	acetylation	[1]
427	EPGPTTPKEPEPTTT	acetylation	[1]
548	PEPTTPKKPEPTTPK	acetylation	[1]
555	KPEPTTPKEPVPTTP	acetylation	[1]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. 

Sequence Annotation

 DOMAIN 26 69 SMB 1.
 DOMAIN 66 108 SMB 2.
 REPEAT 317 324 1; approximate.
 REPEAT 325 332 2; approximate.
 REPEAT 333 340 3; approximate.
 REPEAT 349 356 4; approximate.
 REPEAT 357 364 5.
 REPEAT 365 371 6; approximate.
 REPEAT 372 379 7.
 REPEAT 380 387 8.
 REPEAT 388 395 9.
 REPEAT 396 403 10.
 REPEAT 404 411 11.
 REPEAT 412 418 12; approximate.
 REPEAT 419 426 13.
 REPEAT 427 434 14.
 REPEAT 435 442 15.
 REPEAT 443 450 16; approximate.
 REPEAT 451 458 17.
 REPEAT 459 466 18.
 REPEAT 467 474 19.
 REPEAT 475 482 20.
 REPEAT 483 490 21.
 REPEAT 491 498 22.
 REPEAT 499 506 23.
 REPEAT 507 514 24.
 REPEAT 515 522 25.
 REPEAT 523 530 26.
 REPEAT 531 538 27.
 REPEAT 539 546 28.
 REPEAT 547 554 29.
 REPEAT 555 562 30.
 REPEAT 563 570 31.
 REPEAT 571 578 32.
 REPEAT 579 586 33.
 REPEAT 587 594 34.
 REPEAT 595 602 35.
 REPEAT 603 610 36.
 REPEAT 611 618 37.
 REPEAT 797 840 Hemopexin 1.
 REPEAT 841 888 Hemopexin 2.
 REGION 317 618 37 X 8 AA repeats of K-X-P-X-P-T-T-X.
 CARBOHYD 109 109 N-linked (GlcNAc...) (Potential).
 CARBOHYD 938 938 N-linked (GlcNAc...) (Potential).
 DISULFID 30 46 Alternate (By similarity).
 DISULFID 30 34 By similarity.
 DISULFID 34 64 Alternate (By similarity).
 DISULFID 44 57 Alternate (By similarity).
 DISULFID 44 46 By similarity.
 DISULFID 50 56 By similarity.
 DISULFID 57 64 By similarity.
 DISULFID 70 86 Alternate (By similarity).
 DISULFID 70 74 By similarity.
 DISULFID 74 104 Alternate (By similarity).
 DISULFID 84 97 Alternate (By similarity).
 DISULFID 84 86 By similarity.
 DISULFID 90 96 By similarity.
 DISULFID 97 104 By similarity.
 DISULFID 795 1053  

Keyword

 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Proteoglycan; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1054 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0030247; F:polysaccharide binding; IEA:InterPro.
 GO:0005044; F:scavenger receptor activity; IEA:InterPro.
 GO:0071425; P:hematopoietic stem cell proliferation; IMP:MGI.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IMP:MGI.
 GO:0042127; P:regulation of cell proliferation; IMP:MGI. 

Interpro

 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR018486; Hemopexin_CS.
 IPR020436; Somatomedin_B_chordata.
 IPR001212; Somatomedin_B_dom. 

Pfam

 PF00045; Hemopexin
 PF01033; Somatomedin_B 

SMART

 SM00120; HX
 SM00201; SO 

PROSITE

 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2
 PS00524; SMB_1
 PS50958; SMB_2 

PRINTS

 PR00022; SOMATOMEDINB.