UniProt Accession

 TPM4_HUMAN; P67936; P07226; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4 

Genbank Protein ID

 X05276; AK023385; AK315076; BT019634; CH471106; BC002827; BC037576; BC067225; M12127 

Genbank Nucleotide ID

 CAA28888.1; BAB14554.1; BAG37545.1; AAV38440.1; EAW84521.1; AAH02827.1; AAH37576.1; AAH67225.1; AAA36774.1 

Protein Name

 Tropomyosin alpha-4 chain 

Protein Synonyms/Alias

 TM30p1; Tropomyosin-4 

Gene Name

 TPM4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	EQAEADKKAAEDKCK	ubiquitination	[1]
37	KAAEDKCKQVEEELT	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 177 177 N6-acetyllysine.
 MOD_RES 215 215 N6-acetyllysine.  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Calcium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Metal-binding; Muscle protein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031941; C:filamentous actin; IEA:Compara.
 GO:0005862; C:muscle thin filament tropomyosin; TAS:ProtInc.
 GO:0002102; C:podosome; IEA:Compara.
 GO:0001725; C:stress fiber; IDA:MGI.
 GO:0005509; F:calcium ion binding; NAS:UniProtKB.
 GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
 GO:0030049; P:muscle filament sliding; TAS:Reactome.
 GO:0006979; P:response to oxidative stress; IEP:BHF-UCL. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.