CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027500
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial trifunctional protein alpha subunit, isoform B 
Protein Synonyms/Alias
  
Gene Name
 Mtpalpha 
Gene Synonyms/Alias
 CG4389; Dmel_CG4389 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
177LDMELTGKQVRADRAacetylation[1]
227ANDLASGKLRVNREKacetylation[1]
265TARKQVLKASNGLYPacetylation[1]
379RGIGQVQKGLETAVKacetylation[1]
478HYFSPVDKMQLLEIIacetylation[1]
542LQEGVDPKDLDQYTKacetylation[1]
549KDLDQYTKKFGFPVGacetylation[1]
616IFLYDGQKRGTRPVNacetylation[1]
729QTLLDMAKDPSKKFYacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Lyase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 744 AA 
Protein Sequence
MSTNPAPVAN KHLHTKVVNG VLVIKIDSPN AKVNSLGSEV SDEFERVIKD LETNPAVNSA 60
VLISGKPGCF VAGADIGMLE ACQTAEEATL ISHGAQVMFD RMERSKKPIV AAISGVCLGG 120
GLELALACHY RIATKDSKTK LGLPEVMLGL LPGGGGTVRL PKLTSVPTAL DMELTGKQVR 180
ADRAKRLGIV DLLVDPLGPG LQPAEQNTIE YLEKTAVQVA NDLASGKLRV NREKSGLVSK 240
IQSFVMDTDF VKNKIFDTAR KQVLKASNGL YPAPLKILDV IRAGVDKGTD AGYEAERKGF 300
GELSATPESK GLIALFRGQT ECKKNRFGKP ERPVKTVGVL GAGLMGAGIV QVSVDKGYQV 360
VMKDATEAGL ARGIGQVQKG LETAVKRKRI SALERDQTLA SLRPTLDYSD FKNADIIIEA 420
VFEDIKVKHR VIKELEAVVP EHCVIATNTS AIPITKIAAG SSRPEKVVGM HYFSPVDKMQ 480
LLEIITHPGT SKDTIAQAVA VGLKQGKVVI TVGDGPGFYT TRILSTMLSE AIRLLQEGVD 540
PKDLDQYTKK FGFPVGAATL ADEVGIDVGS HIAVDLAKAF GERFSGGNLE VMNDLVLAGF 600
LGRKSGKGIF LYDGQKRGTR PVNNDALEIV KQKYALVSKG ANAPEDLTLR MVSRFINEAV 660
LCLEEKILDS PLEGDVGAVF GLGFPPFSGG PFRWVDQYGA GKLVSKMQSY AELYGAPFKP 720
AQTLLDMAKD PSKKFYPKTG SSKL 744 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0016507; C:mitochondrial fatty acid beta-oxidation multienzyme complex; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:FlyBase.
 GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:EC.
 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0004300; F:enoyl-CoA hydratase activity; IEA:EC.
 GO:0016509; F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity; IEA:EC.
 GO:0016508; F:long-chain-enoyl-CoA hydratase activity; IEA:EC.
 GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
 GO:0006635; P:fatty acid beta-oxidation; IMP:FlyBase.
 GO:0042594; P:response to starvation; IMP:FlyBase.
 GO:0042060; P:wound healing; IMP:FlyBase. 
Interpro
 IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
 IPR006108; 3HC_DH_C.
 IPR008927; 6-PGluconate_DH_C-like.
 IPR001753; Crotonase_core_superfam.
 IPR013328; DH_multihelical.
 IPR018376; Enoyl-CoA_hyd/isom_CS.
 IPR012803; Fa_ox_alpha_mit.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00725; 3HCDH
 PF02737; 3HCDH_N
 PF00378; ECH 
SMART
  
PROSITE
 PS00166; ENOYL_COA_HYDRATASE 
PRINTS