CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038742
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Intersectin-2 
Protein Synonyms/Alias
  
Gene Name
 Itsn2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
584SGISLLHKKSSEKEEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1658 AA 
Protein Sequence
MMAQFPTAMN GGPNMWAITS EERTKHDKQF DNLKPSGGYI TGDQARTFFL QSGLPAPVLA 60
EIWALSDLNK DGKMDQQEFS IAMKLIKLKL QGQQLPVVLP PIMKQPPMFS PLISARFGMG 120
SMPNLSIHQP LPPVAPIATP LSSATSGTSI PPLMMPAPLV PSVSTSSLPN GTASLIQPLS 180
IPYSSSTLPH ASSYSLMMGG FGGASIQKAQ SLIDLGSSSS TSSTASLSGN SPKTGTSEWA 240
VPQPSRLKYR QKFNSLDKGM SGYLSGFQAR NALLQSNLSQ TQLATIWTLA DIDGDGQLKA 300
EEFILAMHLT DMAKAGQPLP LTLPPELVPP SFRGGKQVDS VNGTLPSYQK TQEEEPQKKL 360
PVTFEDKRKA NYERGNMELE KRRQVLMEQQ QREAERKAQK EKEEWERKQR ELQEQEWKKQ 420
LELEKRLEKQ RELERQREEE RRKEIERREA AKQELERQRR LEWERLRRQE LLSQKTREQE 480
DIVRLSSRKK SLHLELEAVN GKHQQISGRL QDVQIRKQTQ KTELEVLDKQ CDLEIMEIKQ 540
LQQELKEYQN KLIYLVPEKQ LLNERIKNMQ LSNTPDSGIS LLHKKSSEKE ELCQRLKEQL 600
DALEKETASK LSEMDSFNNQ LKELRESYNT QQLALEQLHK IKRDKLKEIE RKRLEQIQKK 660
KLEDEAARKA KQGKENLWRE SIRKEEEEKQ KRLQEEKSQD KTQEEERKAE AKQSETASAL 720
VNYRALYPFE ARNHDEMSFS SGDIIQVDEK TVGEPGWLYG SFQGKFGWFP CNYVEKVLSS 780
EKALSPKKAL LPPTVSLSAT STSSQPPASV TDYHNVSFSN LTVNTTWQQK SAFTRTVSPG 840
SVSPIHGQGQ AVENLKAQAL CSWTAKKENH LNFSKHDVIT VLEQQENWWF GEVHGGRGWF 900
PKSYVKLIPG NEVQRGEPEA LYAAVTKKPT STAYPVTSTA YPVGEDYIAL YSYSSVEPGD 960
LTFTEGEEIL VTQKDGEWWT GSIGERTGIF PSNYVRPKDQ ENFGNASKSG ASNKKPEIAQ 1020
VTSAYAASGT EQLSLAPGQL ILILKKNTSG WWQGELQARG KKRQKGWFPA SHVKLLGPSS 1080
ERTMPTFHAV CQVIAMYDYM ANNEDELNFS KGQLINVMNK DDPDWWQGET NGLTGLFPSN 1140
YVKMTTDSDP SQQWCADLQA LDTMQPTERK RQGYIHELIQ TEERYMDDLQ LVIEVFQKRM 1200
AESGFLTEAD MALIFVNWKE LIMSNTKLLR ALRVRKKTGG EKMPVQMIGD ILAAELSHMQ 1260
AYIRFCSCQL NGATLLQQKT DEDTDFKEFL KKLASDPRCK GMPLSSFLLK PMQRITRYPL 1320
LIRSILENTP QSHVDHSSLK LALERAEELC SQVNEGVREK ENSDRLEWIQ AHVQCEGLAE 1380
QLIFNSLTNC LGPRKLLHSG KLYKTKSNKE LHAFLFNDFL LLTYLVRQFA AASGHEKLFN 1440
SKSSAQFRMY KTPIFLNEVL VKLPTDPSSD EPVFHISHID RVYTLRTDNI NERTAWVQKI 1500
KGASEQYIDT EKKKREKAYQ ARSQKTSGIG RLMVHVIEAT ELKACKPNGK SNPYCEVSMG 1560
SQSYTTRTLQ DTLNPKWNFN CQFFIKDLYQ DVLCLTMFDR DQFSPDDFLG RTEVPVAKIR 1620
TEQESKGPTT RRLLLHEVPT GEVWVRFDLQ LFEQKTLL 1658 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0006897; P:endocytosis; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR000219; DH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000261; EPS15_homology.
 IPR027029; Intersectin-2.
 IPR000108; p67phox.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF00168; C2
 PF00621; RhoGEF
 PF00018; SH3_1
 PF07653; SH3_2 
SMART
 SM00239; C2
 SM00054; EFh
 SM00027; EH
 SM00233; PH
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS50004; C2
 PS50010; DH_2
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS50031; EH
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS
 PR00499; P67PHOX.
 PR00452; SH3DOMAIN.