| Tag | Content |
|---|
| CPLM ID | CPLM-018107 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein BANP |
Protein Synonyms/Alias | Btg3-associated nuclear protein; Scaffold/matrix-associated region-1-binding protein |
Gene Name | Banp |
Gene Synonyms/Alias | Smar1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 287 | GQGKHGKKQLDPLTI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest and inhibits tumor growth. |
Sequence Annotation | DOMAIN 234 330 BEN.
REGION 160 350 Interaction with CUX1 and HDAC1.
REGION 328 357 Necessary and sufficient for TP53
REGION 350 400 DNA-binding.
MOD_RES 347 347 Phosphoserine (Probable). |
Keyword | Alternative splicing; Cell cycle; Chromatin regulator; Coiled coil; Complete proteome; Developmental protein; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 548 AA |
Protein Sequence | MMSEQDLADV VQIAVEDLSP DHPVVLENHV VTDDDEPALK RQRLEINCQD PSIKSFLYSI 60
NQTICLRLDS IEAKLQALEA TCKSLEEKLD LVTNKQHSPI QVPMVAGSPL GATQTCNKVR 120
CVVPQTTVIL NNDRQNAIVA KMEDPLSNRA PDSLENIISN AVPGRRQNTI VVKVPGQDDS 180
HNEDGESGSE ASDSVSNCGQ PGSQNIGSNV TLITLNSEED YPNGTWLGDE NNPEMRVRCA 240
IIPSDMLHIS TNCRTAEKMA LTLLDYLFHR EVQAVSNLSG QGKHGKKQLD PLTIYGIRCH 300
LFYKFGITES DWYRIKQSID SKCRTAWRRK QRGQSLAVKS FSRRTPSSSS YSASETMMGT 360
PPPTSELQQS QPQALHYALA NAQQVQIHQI GEDGQVQVIP QGHLHIAQVP QGEQVQITQD 420
SEGNLQIHHV GQDGQSWGLC QNPIPVSGDS VAQANPSQLW PLGGDTLDLP AGNEMIQVLQ 480
GAQLIAVASS DPAATGVDGS PLQGSDIQVQ YVQLAPVSDH TAAAQTAEAL QPTLQPDMQL 540
EHGAIQIQ 548 |
Gene Ontology | GO:0005634; C:nucleus; IDA:MGI. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0002039; F:p53 binding; IDA:MGI. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0042177; P:negative regulation of protein catabolic process; IDA:MGI. GO:0034504; P:protein localization to nucleus; IDA:MGI. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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