CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009117
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Forkhead box protein L2 
Protein Synonyms/Alias
  
Gene Name
 FOXL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25PETGRTVKEPEGPPPsumoylation[1]
114SLNECFIKVPREGGGsumoylation[2]
150YRRRRRMKRPFRPPPsumoylation[2]
Reference
 [1] Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene.
 Kuo FT, Bentsi-Barnes IK, Barlow GM, Bae J, Pisarska MD.
 Cell Signal. 2009 Dec;21(12):1935-44. [PMID: 19744555]
 [2] The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.
 Marongiu M, Deiana M, Meloni A, Marcia L, Puddu A, Cao A, Schlessinger D, Crisponi L.
 PLoS One. 2010 Mar 2;5(3):e9477. [PMID: 20209145] 
Functional Description
 Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. 
Sequence Annotation
 DNA_BIND 54 148 Fork-head.
 CROSSLNK 25 25 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Differentiation; Disease mutation; DNA-binding; Isopeptide bond; Nucleus; Polymorphism; Premature ovarian failure; Reference proteome; Transcription; Transcription regulation; Triplet repeat expansion; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MMASYPEPED AAGALLAPET GRTVKEPEGP PPSPGKGGGG GGGTAPEKPD PAQKPPYSYV 60
ALIAMAIRES AEKRLTLSGI YQYIIAKFPF YEKNKKGWQN SIRHNLSLNE CFIKVPREGG 120
GERKGNYWTL DPACEDMFEK GNYRRRRRMK RPFRPPPAHF QPGKGLFGAG GAAGGCGVAG 180
AGADGYGYLA PPKYLQSGFL NNSWPLPQPP SPMPYASCQM AAAAAAAAAA AAAAGPGSPG 240
AAAVVKGLAG PAASYGPYTR VQSMALPPGV VNSYNGLGGP PAAPPPPPHP HPHPHAHHLH 300
AAAAPPPAPP HHGAAAPPPG QLSPASPATA APPAPAPTSA PGLQFACARQ PELAMMHCSY 360
WDHDSKTGAL HSRLDL 376 
Gene Ontology
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0043028; F:cysteine-type endopeptidase regulator activity involved in apoptotic process; IMP:UniProtKB.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0030331; F:estrogen receptor binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0006309; P:apoptotic DNA fragmentation; IMP:UniProtKB.
 GO:0030154; P:cell differentiation; NAS:UniProtKB.
 GO:0060026; P:convergent extension; IBA:RefGenome.
 GO:0048048; P:embryonic eye morphogenesis; IBA:RefGenome.
 GO:0002074; P:extraocular skeletal muscle development; IMP:UniProtKB.
 GO:0019101; P:female somatic sex determination; IBA:RefGenome.
 GO:0060014; P:granulosa cell differentiation; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IBA:RefGenome.
 GO:0042703; P:menstruation; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0001541; P:ovarian follicle development; IMP:UniProtKB.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome. 
Interpro
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00250; Fork_head 
SMART
 SM00339; FH 
PROSITE
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 
PRINTS
 PR00053; FORKHEAD.