| Tag | Content |
|---|
| CPLM ID | CPLM-018138 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nicalin |
Protein Synonyms/Alias | Nicastrin-like protein |
Gene Name | Ncln |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 99 | FSYEHYQKALRQSAG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning (By similarity). |
Sequence Annotation | CARBOHYD 241 241 N-linked (GlcNAc...) (Potential).
CARBOHYD 428 428 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 563 AA |
Protein Sequence | MLEEAGEVLE NVLKASCLPL GFIVFLPAVL LLVAPPLPAA DAAHEFTVYR MQQYDLQGQP 60
YGTRNAVLNT EARTVDADVL SRRCVLMRLL DFSYEHYQKA LRQSAGAVVI ILPRAMAAVP 120
QDVVRQFMEI EPEMLAMETV VPVYFAVEDE ALLSIYEQTQ AASASQGSAS AAEVLLHTAT 180
ANGFQMVTSG AQSQAVSDWL ITSVEGRLTG LGGEDLPTIV IVAHYDAFGV APWLSLGADS 240
NGSGISVLLE LARLFSRLYT YKRTHAAYNL LFFASGGGKF NYQGTKRWLE DSLDHTDSSL 300
LQDNVAFVLC LDTVGRGSHL RLHVSKPPRE GTLQHAFLRE LETVAAHQFP DVSFSMVHKK 360
INLADDVLAW EHERFAIRRL PAFTLSHLES HRAGPRSSIM DVRSRVDSKT LTRNTRIIAE 420
ALTRVIYNLT EKGTPPDMPV FTEQMQVQEE QIDSVMDWLT NQPRAAQLLD KDGTFLSTLE 480
HFLSRYLKDV RQHHVKADKR DPEFVFYDQL KQVMNAYRVK PAIFDLLLAL CIGAYLGMAY 540
TAVQHFHVLY KTVQRLLLKA KAQ 563 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:Compara. GO:0008233; F:peptidase activity; IEA:InterPro. GO:0006508; P:proteolysis; IEA:InterPro. GO:0009966; P:regulation of signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |