CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012347
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Next to BRCA1 gene 1 protein 
Protein Synonyms/Alias
 Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B 
Gene Name
 NBR1 
Gene Synonyms/Alias
 1A13B; KIAA0049; M17S2; MIG19 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
108RLAARAGKKPLAHYSubiquitination[1]
109LAARAGKKPLAHYSSubiquitination[1]
172VVNETVEKLEQKLHEubiquitination[1]
274SEPFCHSKYSTPRLPubiquitination[1]
295RLQKQVDKNFLKAEKubiquitination[1]
299QVDKNFLKAEKQRLRubiquitination[1]
328KQLKLHRKIHLWNSIubiquitination[1]
394QPGTKFIKHWRMKNTubiquitination[1]
399FIKHWRMKNTGNVKWubiquitination[2]
405MKNTGNVKWSADTKLubiquitination[1]
411VKWSADTKLKFMWGNubiquitination[1]
464SHWRLSHKGQQFGPRubiquitination[1]
499KGMISSSKTDDLTCQubiquitination[1]
515EETFLLAKEERQLGEubiquitination[1]
537TAACIPQKAKNVASEubiquitination[1]
601HDSPLIEKPGLGQIEubiquitination[1]
627PDSMVSVKRKAENIAubiquitination[1]
629SMVSVKRKAENIASVubiquitination[1]
767LERGAEGKPGVEAGQubiquitination[1, 2]
887SIAGGLVKGALSVAAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. 
Sequence Annotation
 DOMAIN 43 71 OPR.
 DOMAIN 913 957 UBA.
 ZN_FING 211 257 ZZ-type.
 REGION 542 636 ATG8 family protein-binding.
 REGION 727 738 ATG8 family protein-binding.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Lysosome; Metal-binding; Polymorphism; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 966 AA 
Protein Sequence
MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD EENEEVSINS 60
QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK RLAARAGKKP LAHYSSLVRV 120
LGSDMKTPED PAVQSFPLVP CDTDQPQDKP PDWFTSYLET FREQVVNETV EKLEQKLHEK 180
LVLQNPSLGS CPSEVSMPTS EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC 240
EDCEAGPYGH DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA 300
EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES LLQSNTLMLP 360
LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN TGNVKWSADT KLKFMWGNLT 420
LASTEKKDVL VPCLKAGHVG VVSVEFIAPA LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP 480
FPSEESPDNI EKGMISSSKT DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN 540
VASERELYIP SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE 600
KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC ETVIRSLTLD 660
AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA VMEEEEDEED EEEEDELKDE 720
VQSQSSASSE DYIIILPECF DTSRPLGDSM YSSALSQPGL ERGAEGKPGV EAGQEPAEAG 780
ERLPGGENQP QEHSISDILT TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV 840
TIPEVSSVPD QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL 900
FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV TELLQLNNND 960
WYSQRY 966 
Gene Ontology
 GO:0005776; C:autophagic vacuole; IEA:UniProtKB-SubCell.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005770; C:late endosome; ISS:UniProtKB.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0031430; C:M band; IEA:UniProtKB-SubCell.
 GO:0000407; C:pre-autophagosomal structure; IEA:Compara.
 GO:0051019; F:mitogen-activated protein kinase binding; ISS:BHF-UCL.
 GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016236; P:macroautophagy; IDA:UniProtKB.
 GO:0045668; P:negative regulation of osteoblast differentiation; ISS:BHF-UCL.
 GO:0051259; P:protein oligomerization; IDA:UniProtKB.
 GO:0030500; P:regulation of bone mineralization; ISS:BHF-UCL.
 GO:0032872; P:regulation of stress-activated MAPK cascade; ISS:BHF-UCL. 
Interpro
 IPR000270; OPR_PB1.
 IPR009060; UBA-like.
 IPR015940; UBA/transl_elong_EF1B_N_euk.
 IPR000433; Znf_ZZ. 
Pfam
 PF00564; PB1
 PF00569; ZZ 
SMART
 SM00666; PB1
 SM00291; ZnF_ZZ 
PROSITE
 PS50030; UBA
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS