| Tag | Content |
|---|
| CPLM ID | CPLM-000487 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 26S protease regulatory subunit 8 |
Protein Synonyms/Alias | |
Gene Name | Pros45 |
Gene Synonyms/Alias | DUG; Ug; CG1489 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 87 | DKKKVLVKVHPEGKF | acetylation | [1] | | 329 | EARLDILKIHSRKMN | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). |
Sequence Annotation | NP_BIND 189 196 ATP (Potential). |
Keyword | ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Proteasome; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 405 AA |
Protein Sequence | MTVTNRMEIE SAYHKGEGFR SYYIQKIEEL QLVVAEKHQN LRRLQAQRNE LNAKVRMLRE 60
ELQLLQEQGS YVGEVVKPMD KKKVLVKVHP EGKFVVDLDK NIDINDVTPN CRVALRNESY 120
TLHKILPNKV DPLVSLMMVE KVPDSTYEMV GGLDKQIKEI KEVIELPVKH PELFDALGIA 180
QPKGVLLYGP PGTGKTLLAR AVAHHTECTF IRVSGSELVQ KFIGEGSRMV RELFVMAREH 240
APSIIFMDEI DSIGSSRIES GSGGDSEVQR TMLELLNQLD GFEATKNIKV IMATNRIDIL 300
DPALLRPGRI DRKIEFPPPN EEARLDILKI HSRKMNLTRG INLRKIAELM PGASGAEVKG 360
VCTEAGMYAL RERRVHVTQE DFEMAVAKVM QKDSEKNMSI KKLWK 405 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:FlyBase. GO:0005875; C:microtubule associated complex; IDA:FlyBase. GO:0005634; C:nucleus; IDA:FlyBase. GO:0008540; C:proteasome regulatory particle, base subcomplex; ISS:FlyBase. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:FlyBase. GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |