UniProt Accession

 K1C17_HUMAN; Q04695; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2; Q6IP98; Q8N1P6 

Genbank Protein ID

 Z19574; X62571; AK095342; AC022596; AL353997; BC000159; BC011901; BC056421; BC072018; BC072019; S78515; EF608068; EF608069; EF608070; EF608071 

Genbank Nucleotide ID

 CAA79626.1; CAA44451.1; BAC04534.1; AAH00159.2; AAH11901.1; AAH56421.1; AAH72018.1; AAH72019.1; AAB34565.1; ABQ96595.1; ABQ96596.1; ABQ96597.1; ABQ96598.1 

Protein Name

 Keratin, type I cytoskeletal 17 

Protein Synonyms/Alias

 39.1; Cytokeratin-17; CK-17; Keratin-17; K17 

Gene Name

 KRT17 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	FTSSSSIKGSSGLGG	ubiquitination	[1, 2]
101	RLASYLDKVRALEEA	ubiquitination	[1]
172	AADDFRTKFETEQAL	ubiquitination	[1, 3]
278	AEDWFFSKTEELNRE	ubiquitination	[1]
297	SELVQSGKSEISELR	ubiquitination	[1]
400	AHLTQYKKEPVTTRQ	ubiquitination	[4]
419	VEEVQDGKVISSREQ	ubiquitination	[1]

Reference

 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity). 

Sequence Annotation

 REGION 1 83 Head.
 REGION 84 392 Rod.
 REGION 84 120 Coil 1A.
 REGION 102 116 Peptide epitope S1; induces T-cell and
 REGION 121 138 Linker 1.
 REGION 139 230 Coil 1B.
 REGION 153 167 Peptide epitope S2; induces T-cell
 REGION 231 250 Linker 12.
 REGION 251 392 Coil 2.
 REGION 332 346 Peptide epitope S4; induces T-cell and
 REGION 393 432 Tail.
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 39 39 Phosphoserine.
 MOD_RES 319 319 Phosphoserine (By similarity).  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Ectodermal dysplasia; Intermediate filament; Keratin; Palmoplantar keratoderma; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 432 AA 

Protein Sequence

Gene Ontology

 GO:0071944; C:cell periphery; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005882; C:intermediate filament; TAS:ProtInc.
 GO:0032395; F:MHC class II receptor activity; IDA:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0008544; P:epidermis development; TAS:ProtInc.
 GO:0045109; P:intermediate filament organization; IEA:Compara.
 GO:0031424; P:keratinization; IEA:Compara.
 GO:0002009; P:morphogenesis of an epithelium; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0051798; P:positive regulation of hair follicle development; IEA:Compara.
 GO:0045727; P:positive regulation of translation; IEA:Compara. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR002957; Keratin_I.
 IPR009053; Prefoldin. 

Pfam

 PF00038; Filament 

SMART

  

PROSITE

 PS00226; IF 

PRINTS

 PR01248; TYPE1KERATIN.