| Tag | Content |
|---|
| CPLM ID | CPLM-001393 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Origin recognition complex subunit 4 |
Protein Synonyms/Alias | |
Gene Name | Orc4 |
Gene Synonyms/Alias | Orc4l |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 201 | DILELLEKRVKSRFS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. |
Sequence Annotation | NP_BIND 65 72 ATP (Potential). |
Keyword | ATP-binding; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 433 AA |
Protein Sequence | MSSRKTKSNA HAECLSQVQR ILRERFCHHS PHSNLFGVQV QYKHLIELLK RTAIYGESNS 60
VLIVGPRGSG KTTLLNHALK ELMEIEVSEN VIQVHLNGLL QTNEKIALKE ITRQLNLDNV 120
VEDKVFGSFA ENLSFLLEAL QKGDRTSSCP VIFILDEFDI FAHQKNQTLL YNLFDISQSA 180
QTPVAVIGLT CRLDILELLE KRVKSRFSHR QIHLMNSFDF PQYLKIFKEQ LSLPAEFPDK 240
AFAERWNENV HCLSEDSTVL EVLQKHFSVN KNLQSLHMLL MLALNRVTVS HPFMTSADLM 300
EAQHMCSLDS KANIVHGLSV LEICLIIAMK HLNDIYEEEP FNFQMVYNEF QKFIQRKAHS 360
VYNFEKPVVM KAFEHLQQLE LIKPVERTSV NSQREYQLVK LLLDNTQIMN ALQKYSNCPT 420
DVRQWATSSL SWL 433 |
Gene Ontology | GO:0005664; C:nuclear origin of replication recognition complex; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003688; F:DNA replication origin binding; IEA:Compara. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0006260; P:DNA replication; TAS:MGI. GO:0006270; P:DNA replication initiation; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |