UniProt Accession

 PDE6D_HUMAN; O43924; O43250 

Genbank Protein ID

 AF045999; AF022912; AF042835; AF042833; AF042834; AJ001626; BT007278; BC007831 

Genbank Nucleotide ID

 AAC39720.1; AAB87872.1; AAC25953.1; AAC25953.1; AAC25953.1; CAA04880.1; AAP35942.1; AAH07831.1 

Protein Name

 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta 

Protein Synonyms/Alias

 GMP-PDE delta; Protein p17 

Gene Name

 PDE6D 

Gene Synonyms/Alias

 PDED 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	LRDAETGKILWQGTE	ubiquitination	[1]
73	SSTEQMEKFRLEQKV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; cGMP; Complete proteome; Reference proteome; Sensory transduction; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
 GO:0005095; F:GTPase inhibitor activity; ISS:UniProtKB.
 GO:0033124; P:regulation of GTP catabolic process; ISS:UniProtKB.
 GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR008015; GMP_PDE_delta.
 IPR014756; Ig_E-set.
 IPR017287; Rhodop-sen_GMP-Pdiesterase_dsu. 

Pfam

 PF05351; GMP_PDE_delta 

SMART

  

PROSITE

  

PRINTS