CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001432
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucosamine-6-phosphate isomerase 1 
Protein Synonyms/Alias
 Glucosamine-6-phosphate deaminase 1; GNPDA 1; GlcN6P deaminase 1; Oscillin 
Gene Name
 Gnpda1 
Gene Synonyms/Alias
 Gnpi 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
57QKLIEYYKNGDLSFQubiquitination[1]
160LVSRTRVKTLAMDTIubiquitination[1]
273VDPLYSIKEKEIQKSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). 
Sequence Annotation
 ACT_SITE 72 72 Proton acceptor; for enolization step (By
 ACT_SITE 141 141 For ring-opening step (By similarity).
 ACT_SITE 143 143 Proton acceptor; for ring-opening step
 ACT_SITE 148 148 For ring-opening step (By similarity).  
Keyword
 Carbohydrate metabolism; Complete proteome; Cytoplasm; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 289 AA 
Protein Sequence
MKLIILEHYS QASEWAAKYI RNRIIQFNPG PDKYFTLGLP TGSTPLGCYQ KLIEYYKNGD 60
LSFQYVKTFN MDEYVGLPRD HPESYHSFMW NNFFKHIDIH PENTHILDGN AADLQAECDA 120
FEEKIQAAGG IELFVGGIGP DGHIAFNEPG SSLVSRTRVK TLAMDTILAN ARFFDGDLAK 180
VPTMALTVGV GTVMDAKEVM ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTVFVCD 240
EDATLELKVK TVKYFKGLML VHNKLVDPLY SIKEKEIQKS QSAKKPYSD 289 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0004342; F:glucosamine-6-phosphate deaminase activity; ISS:UniProtKB.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0007340; P:acrosome reaction; TAS:MGI.
 GO:0006002; P:fructose 6-phosphate metabolic process; ISA:MGI.
 GO:0046370; P:fructose biosynthetic process; ISA:MGI.
 GO:0006091; P:generation of precursor metabolites and energy; ISS:UniProtKB.
 GO:0006043; P:glucosamine catabolic process; ISS:UniProtKB.
 GO:0006044; P:N-acetylglucosamine metabolic process; IEA:InterPro. 
Interpro
 IPR006148; Glc/Gal-6P_isomerase.
 IPR004547; Glucosamine6P_isomerase.
 IPR018321; Glucosamine6P_isomerase_CS. 
Pfam
 PF01182; Glucosamine_iso 
SMART
  
PROSITE
 PS01161; GLC_GALNAC_ISOMERASE 
PRINTS