CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBC1 domain family member 10A 
Protein Synonyms/Alias
 TBC1 domain family, member 10A, isoform CRA_e 
Gene Name
 TBC1D10A 
Gene Synonyms/Alias
 hCG_41315 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49KLQQNPGKFDELDMSubiquitination[1, 2, 3, 4]
170KVSPVAHKHLSRQKIubiquitination[3]
234LGSPEKVKACQGQYEubiquitination[3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 420 AA 
Protein Sequence
MLNNWDKWMA KKHKKIRLRC QKGIPPSLRG RAWQYLSGGK VKLQQNPGKF DELDMSPGDP 60
KWLDVIERDL HRQFPFHEMF VSRGGHGQQD LFRVLKAYTL YRPEEGYCQA QAPIAAVLLM 120
HMPAEQAFWC LVQICEKYLP GYYSEKLEAI QLDGEILFSL LQKVSPVAHK HLSRQKIDPL 180
LYMTEWFMCA FSRTLPWSSV LRVWDMFFCE GVKIIFRVGL VLLKHALGSP EKVKACQGQY 240
ETIERLRSLS PKIMQEAFLV QEVVELPVTE RQIEREHLIQ LRRWQETRGE LQCRSPPRLH 300
GAKAILDAEP GPRPALQPSP SIRLPLDAPL PGSKAKPKPP KQAQKEQRKQ MKGRGQLEKP 360
PAPNQAMVVA AAGDACPPQH VPPKDSAPKD SAPQDLAPQV SAHHRSQESL TSQESEDTYL 420 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF00566; RabGAP-TBC 
SMART
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS