| Tag | Content |
|---|
| CPLM ID | CPLM-024209 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 382 |
Protein Synonyms/Alias | KRAB/zinc finger suppressor protein 1; KS1; Multiple zinc finger and krueppel-associated box protein KS1 |
Gene Name | Znf382 |
Gene Synonyms/Alias | Zfp382 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 405 | QRTHTGEKPYQCAEC | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Functions as a sequence-specific transcriptional repressor. |
Sequence Annotation | DOMAIN 12 83 KRAB.
ZN_FING 211 233 C2H2-type 1.
ZN_FING 295 317 C2H2-type 2.
ZN_FING 323 345 C2H2-type 3.
ZN_FING 351 373 C2H2-type 4.
ZN_FING 379 401 C2H2-type 5.
ZN_FING 407 429 C2H2-type 6.
ZN_FING 435 457 C2H2-type 7.
ZN_FING 463 485 C2H2-type 8.
ZN_FING 491 513 C2H2-type 9.
ZN_FING 519 541 C2H2-type 10.
REGION 1 105 Mediates interaction with TRIM28.
REGION 10 51 Represses transcription.
REGION 75 210 Represses transcription.
REGION 295 549 Required for transcriptional repression |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 549 AA |
Protein Sequence | MNCHSVPLQG PVSFKDVTVD FTQEEWQRLD PAQKALYRDV MLENYCHFIS VGFHITKPDM 60
IRKLEQGEEL WTERMFPSQS YLEDEEVLVK FRDYQDKPPT SIVIINHKKL IKERNNVYEK 120
TLGNNHIISK TLFEYKSDGK VLKNISDFIS RDINPVMGTL GDSSEWEESV LTSEQEKTHP 180
VPTLYKQIGR NLSSSLELAQ HQKTQIPEQR FECDECDSSF LMTEVAFPHD RAHRGVRDFN 240
CSKDEIAFFE KSDLGIHPHN LMEKKCSTYN KYGKLLCRKS VFVMHPRSQV DERPFQCPYC 300
GNSFRRKSYL IEHQRIHTGE KPYICSQCGK AFRQKTALTL HEKTHTDGKP YLCVDCGKSF 360
RQKATLTRHH KTHTGEKAYE CTQCGSAFGK KSYLIDHQRT HTGEKPYQCA ECGKAFIQKT 420
TLTVHQRTHT GEKPYMCSEC GKSFCQKTTL TLHQRIHTGE KPYVCSDCGK SFRQKAILTV 480
HYRIHTGEKS NGCPQCGKAF SRKSNLIRHQ KTHTGEKPYE CHECGKFFSC KSNLVAHQKT 540
HKAETVRFQ 549 |
Gene Ontology | GO:0005634; C:nucleus; IDA:RGD. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:RGD. GO:0001558; P:regulation of cell growth; NAS:RGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |