| Tag | Content |
|---|
| CPLM ID | CPLM-018046 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 |
Protein Synonyms/Alias | Development and differentiation-enhancing factor-like 1; Protein up-regulated in liver cancer 1 |
Gene Name | ASAP3 |
Gene Synonyms/Alias | DDEFL1; UPLC1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 534 | RRDYIMAKYVEHRFA | ubiquitination | [1] | | 639 | YNQPDCLKLLLKGRA | ubiquitination | [1] | | 643 | DCLKLLLKGRALVGT | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Promotes cell proliferation. |
Sequence Annotation | DOMAIN 302 394 PH.
DOMAIN 426 551 Arf-GAP.
REPEAT 585 617 ANK 1.
REPEAT 621 650 ANK 2.
ZN_FING 441 464 C4-type. |
Keyword | 3D-structure; Alternative splicing; ANK repeat; Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 903 AA |
Protein Sequence | MPEQFSVAEF LAVTAEDLSS PAGAAAFAAK MPRYRGAALA REEILEGDQA ILQRIKKAVR 60
AIHSSGLGHV ENEEQYREAV ESLGNSHLSQ NSHELSTGFL NLAVFTREVA ALFKNLIQNL 120
NNIVSFPLDS LMKGQLRDGR QDSKKQLEKA WKDYEAKMAK LEKERDRARV TGGIPGEVAQ 180
DMQRERRIFQ LHMCEYLLKA GESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLFPFI 240
EKLAASVHAL HQAQEDELQK LTQLRDSLRG TLQLESREEH LSRKNSGCGY SIHQHQGNKQ 300
FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSTIN RPPVKLTLLT CQVRPNPEEK 360
KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA FLGEPSAGPG SWGSAGHDGE 420
PHDLTKLLIA EVKSRPGNSQ CCDCGAADPT WLSTNLGVLT CIQCSGVHRE LGVRFSRMQS 480
LTLDLLGPSE LLLALNMGNT SFNEVMEAQL PSHGGPKPSA ESDMGTRRDY IMAKYVEHRF 540
ARRCTPEPQR LWTAICNRDL LSVLEAFANG QDFGQPLPGP DAQAPEELVL HLAVKVANQA 600
SLPLVDFIIQ NGGHLDAKAA DGNTALHYAA LYNQPDCLKL LLKGRALVGT VNEAGETALD 660
IARKKHHKEC EELLEQAQAG TFAFPLHVDY SWVISTEPGS DSEEDEEEKR CLLKLPAQAH 720
WASGRLDISN KTYETVASLG AATPQGESED CPPPLPVKNS SRTLVQGCAR HASGDRSEVS 780
SLSSEAPETP ESLGSPASSS SLMSPLEPGD PSQAPPNSEE GLREPPGTSR PSLTSGTTPS 840
EMYLPVRFSS ESTRSYRRGA RSPEDGPSAR QPLPRRNVPV GITEGDGSRT GSLPASSVQL 900
LQD 903 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0008060; F:ARF GTPase activator activity; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |