CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038595
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
135ADRHRKRKLLENSSLubiquitination[1]
145ENSSLNSKLLKVNGSubiquitination[1]
385WTAYLRNKVDTYVQFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 482 AA 
Protein Sequence
MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQIPLLN HKRSEKQEKA QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120
LENSAFTADR HRKRKLLENS SLNSKLLKVN GSTTAICATG LRNLGNTCFM NAILQSLRSL 180
VEEFRKTLCA LWQGSQTAFS PESLFYVVWK IMPNFRGYQQ QDAHEFMRYL LDHLHLELQG 240
GFNGVSRSAI LQENSTLSAS NKCCINGAST VVTAIFGGIL QNEVNCLICG TESRKFDPFL 300
DLSLDIPSQF RSKRSKNQEN GPVCSLRDCL RSFTDLEELD ETELYMCHKC KKKQKSTKKF 360
WIQKLPKALC LHLKRFHWTA YLRNKVDTYV QFPLRGLDMK CYLLEPENSG PDSCLYDLAA 420
VVVHHGSGVG SGHYTAYAVH EGRWFHFNDS TVTVTDEETV GKAKAYILFY VERQARAGAE 480
KL 482 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR001607; Znf_UBP. 
Pfam
 PF00443; UCH
 PF02148; zf-UBP 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3
 PS50271; ZF_UBP 
PRINTS