CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024121
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Extended synaptotagmin-1 
Protein Synonyms/Alias
 E-Syt1; Membrane-bound C2 domain-containing protein; vp115 
Gene Name
 Esyt1 
Gene Synonyms/Alias
 Fam62a; Mbc2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
341SSKDKYVKGLIEGKSubiquitination[1]
409DDFLGRMKLDVGKVLacetylation[2]
660RFLGGLVKGKSDPYVacetylation[2]
806LPLRKGTKPPSPYAIacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May play a role as calcium-regulated intrinsic membrane protein (By similarity). 
Sequence Annotation
 DOMAIN 308 409 C2 1.
 DOMAIN 457 550 C2 2.
 DOMAIN 623 724 C2 3.
 DOMAIN 774 866 C2 4.
 DOMAIN 956 1061 C2 5.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 806 806 N6-acetyllysine (By similarity).
 MOD_RES 809 809 Phosphoserine (By similarity).
 MOD_RES 947 947 Phosphoserine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1088 AA 
Protein Sequence
MERSPEEGAG PEPSGQSPAT DSTRERDGGS GVPPAGPGAA SEALAVLTSF GRRLLVLVPV 60
YLAGAAGLSV GFVLFGLALY LGWRRVRDGK ERSLRAARQL LDDEERITAE TLYMSHRELP 120
AWVSFPDVEK AEWLNKIVVQ VWPFLGQYME KLLAETVAPA VRGANPHLQT FTFTRVELGE 180
KPVRIIGVKV HPSQRKDQIL LDLNVSYVGD LQIDVEVKKY FCKAGVKGMQ LHGVLRVILE 240
PLIGDLPIVG AVSMFFIKRP TLDINWTGMT NLLDIPGLSS LSDTMIMDSI AAFLVLPNRL 300
LVPLVPDLQD VAQLRSPLPR GIIRIHLLAA RGLSSKDKYV KGLIEGKSDP YALVRVGTQT 360
FCSRVIDEEL NPHWGETYEV IVHEVPGQEI EVEVFDKDPD KDDFLGRMKL DVGKVLQAGV 420
LDNWYPLQGG QGQVHLRLEW LSLLPDAEKL DQVLQWNRGI TSRPEPPSAA ILVVYLDRAQ 480
DLPLKKGNKE PNPMVQLSVQ DVTQESKATY STNCPVWEEA FRFFLQDPRS QELDVQVKDD 540
SRALTLGALT LPLARLLTAS ELTLDQWFQL SSSGPNSRLY MKLVMRILYL DSSEMRLPTE 600
PGAQDWDSES PETGSSVDAP PRPYHTTPNS HFGTENVLRI HVLEAQDLIA KDRFLGGLVK 660
GKSDPYVKLK VAGRSLRTHV VREDLNPRWN EVFEVIVTSI PGQELDIEVF DKDLDKDDFL 720
GRYKVGLTTV LNSGFLDEWL TLEDVPSGRL HLRLERLSPR PTAAELEEVL QVNSLIQTQK 780
SSELAAALLS VYLERSEDLP LRKGTKPPSP YAILTVGETS HKTKTVSQTS APIWEESASF 840
LIRKPHAESL ELQVRGEGTG TLGSISLPLS ELLQEEQLCL DRWFALSGQG QVLMRVQLGI 900
LVSQHSGVEA HSHSSSSLNE EPEVLGDPTH TASPVLEVRH RLTHGDSPSE ALIGPLGQVK 960
LTVWYHSDEQ KLISIIHSCR ALRQNGRDLP DPYVSVLLLP DKNRGTKRKT SQKKRTLNPE 1020
FNERFEWDLP LDGTLRRKLD VSVKSNSSFM SRERELLGKV QLDLAEIDLS QGAAQWYDLI 1080
DDRDKGGS 1088 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR020477; C2_dom.
 IPR018029; C2_membr_targeting. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS
 PR00360; C2DOMAIN.