CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015112
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell cycle checkpoint protein RAD17 
Protein Synonyms/Alias
  
Gene Name
 Rad17 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
93DNEPWVDKYKPETQHacetylation[1]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity). Essential for embryonic development. May be involved in homologous recombination. 
Sequence Annotation
 NP_BIND 136 143 ATP (Potential).
 REGION 431 688 Interaction with MCM7 (By similarity).
 MOD_RES 55 55 Phosphothreonine (By similarity).
 MOD_RES 647 647 Phosphoserine; by ATR.
 MOD_RES 657 657 Phosphoserine; by ATR.  
Keyword
 ATP-binding; Cell cycle; Complete proteome; Developmental protein; DNA damage; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 688 AA 
Protein Sequence
MSETFLRPKV SSTKVTDWVA PAFDDFEANT AITTITASSL TFSNSSHRRK YLPSTLESNR 60
LSARKRGRLS LEQTHGLETS RERLSDNEPW VDKYKPETQH ELAVHKKKIE EVETWLKAQV 120
LEVKPKQGGS VLLITGPPGC GKTTTIKILS KELGIQVQEW VNPILPDFQK DDYKELLSLE 180
SNFSVVPYQS QIAVFNDFLL RATKYSKLQM LGDDLTTDKK IILVEELPNQ FYRDPNALHE 240
ILRKHVQIGR CPLVFIVSDS VSGDNNQRLL FPRNIQEECS VSNISFNPVA PTIMMKFLNR 300
IVTIEASKNG EKIIVPNKTS LELLCQGCSG DIRSAINSLQ FSSSKGENSS WSKKKRMSLK 360
SDAAISKSKQ KKKHNSTLEN QEIQAIGGKD VSLFLFRALG KILYCKRAPL TELDSPRLPA 420
HLSEHDRDTL LVQPEEIVEM SHMPGDFFNL YLHQNYIDFF AEVDDLVPAS EFLSFADILG 480
GDWNTRSLLR EYSTSVATRG VMHSNKARGF AHCQGGSSFR PLHKPQWFLI QKKYRENCLA 540
AKALFVDFCL PALCLQTQLL PYLALLTIPM RNKAQISFIQ DVGRLPLKRS FGRLKMEALT 600
DRELGLIDPD SGDESPHSGG QPAQEAPGEP AQAAQNADPE TWSLPLSQNS GSDLPASQPQ 660
PFSSKVDMEE EEEEEEDIII EDYDSEET 688 
Gene Ontology
 GO:0000781; C:chromosome, telomeric region; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0000077; P:DNA damage checkpoint; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0007093; P:mitotic cell cycle checkpoint; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0008156; P:negative regulation of DNA replication; IEA:Compara.
 GO:0042325; P:regulation of phosphorylation; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IMP:MGI. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR004582; Checkpoint_prot_Rad17_Rad24.
 IPR018324; Checkpoint_prot_Rad24_fun/met.
 IPR027417; P-loop_NTPase. 
Pfam
  
SMART
 SM00382; AAA 
PROSITE
  
PRINTS