UniProt Accession

 CY24A_HUMAN; P13498; Q14090; Q9BR72 

Genbank Protein ID

 M21186; BT006861; AC116552; BC006465; AH002664 

Genbank Nucleotide ID

 AAA90925.1; AAP35507.1; AAH06465.1; AAA52134.1 

Protein Name

 Cytochrome b-245 light chain 

Protein Synonyms/Alias

 Cytochrome b(558) alpha chain; Cytochrome b558 subunit alpha; Neutrophil cytochrome b 22 kDa polypeptide; Superoxide-generating NADPH oxidase light chain subunit; p22 phagocyte B-cytochrome; p22-phox; p22phox 

Gene Name

 CYBA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
60	EYPRGKRKKGSTMER	ubiquitination	[1]
61	YPRGKRKKGSTMERW	ubiquitination	[1]
71	TMERWGQKYMTAVVK	ubiquitination	[1, 2]
78	KYMTAVVKLFGPFTR	ubiquitination	[1]
137	QWTPIEPKPRERPQI	ubiquitination	[1, 2]
149	PQIGGTIKQPPSNPP	ubiquitination	[1, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. 

Sequence Annotation

 METAL 94 94 Iron (heme axial ligand) (Potential).
 MOD_RES 147 147 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Cell membrane; Chronic granulomatous disease; Complete proteome; Direct protein sequencing; Disease mutation; Electron transport; Heme; Iron; Membrane; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 195 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043020; C:NADPH oxidase complex; IDA:BHF-UCL.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0030141; C:secretory granule; TAS:BHF-UCL.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.
 GO:0071230; P:cellular response to amino acid stimulus; IEA:Compara.
 GO:0071480; P:cellular response to gamma radiation; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0071407; P:cellular response to organic cyclic compound; IEA:Compara.
 GO:0071356; P:cellular response to tumor necrosis factor; IEA:Compara.
 GO:0017004; P:cytochrome complex assembly; IDA:BHF-UCL.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0050665; P:hydrogen peroxide biosynthetic process; ISS:BHF-UCL.
 GO:0006954; P:inflammatory response; IMP:BHF-UCL.
 GO:0045087; P:innate immune response; IMP:BHF-UCL.
 GO:0051701; P:interaction with host; TAS:Reactome.
 GO:0003106; P:negative regulation of glomerular filtration by angiotensin; IEA:Compara.
 GO:0055114; P:oxidation-reduction process; IMP:BHF-UCL.
 GO:0090382; P:phagosome maturation; TAS:Reactome.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:0045730; P:respiratory burst; IMP:BHF-UCL.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0014895; P:smooth muscle hypertrophy; ISS:BHF-UCL.
 GO:0042554; P:superoxide anion generation; IMP:BHF-UCL. 

Interpro

 IPR007732; Cyt_b558_asu. 

Pfam

 PF05038; Cytochrom_B558a 

SMART

  

PROSITE

  

PRINTS