CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017201
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear factor of activated T-cells, cytoplasmic 4 
Protein Synonyms/Alias
 NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3 
Gene Name
 Nfatc4 
Gene Synonyms/Alias
 Nfat3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
682RSPTQSFKFLPVVFKacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation (By similarity). May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. 
Sequence Annotation
 REPEAT 213 229 SP 1.
 REPEAT 277 293 SP 2; approximate.
 DOMAIN 401 582 RHD.
 DOMAIN 586 683 IPT/TIG.
 DNA_BIND 430 437 By similarity.
 REGION 114 119 Calcineurin-binding (By similarity).
 REGION 213 293 2 approximate SP repeats.
 MOTIF 268 270 Nuclear localization signal.
 MOTIF 672 674 Nuclear localization signal.
 MOD_RES 168 168 Phosphoserine; by MAPK7 and MAPK14.
 MOD_RES 170 170 Phosphoserine; by MAPK7 and MAPK14.
 MOD_RES 213 213 Phosphoserine; by MAPK8 and MAPK9 (By
 MOD_RES 217 217 Phosphoserine; by MAPK8 and MAPK9 (By
 MOD_RES 289 289 Phosphoserine; by RPS6KA3 (By
 MOD_RES 334 334 Phosphoserine; by RPS6KA3 (By  
Keyword
 Activator; Alternative splicing; Complete proteome; Cytoplasm; Differentiation; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 901 AA 
Protein Sequence
MGAASCEDEE LEFKLVFGEE KEPPPLGPGG PGEELDSEDT PPCCRLALGE PLPYGAAPIG 60
IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG NAGGAGGGRV LECPSIRITS 120
ISPTPDPPTS LEDTSETWGD GSPRDYPPPE GFGGYREAGG QGGGAFFSPS PGSSSLSSWS 180
FFSDASDEAA LYAACDEVES ELNEAASRFG LSSPLPSPRA SPRPWTPEDP WSLYGPSSGG 240
RAPEDSWLLL SAPGPVPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGPEPPPP 300
PPLPLVRDPS SPGPFDYVGA PPTESIPQKT RRTSSEQAVA LPRSEEPPSC NGKLPSGTED 360
SVAAPGALRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT SALPPLDWPL PSQYEQLELR 420
IEVQPRAHHR AHYETEGSRG AVKAAPGGHP VVKLLGYSEK PLTLQMFIGT ADERSLRPHA 480
FYQVHRITGK MVATASYEAV VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE 540
TDIGRKNTRV RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVET YSPSACSVRG 600
GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEAAVNRLQ SSEVTLTLTI PEYSNKRVSR 660
PVQVYFYVSN GRRKRSPTQS FKFLPVVFKE EPLPDSSLRG FPSTSGPPFG PDVDFSPPRP 720
PYPSYPHEDP AYETPYLSEG FGYSTPALYP QTGPPPSYRS GLRMFPETGG TTGCARLPSV 780
SFLPRPFPGD QYGGQGSSFA LGLPFSPPAP FRPPLPSSPP LEDPFHPQSA IHPLPPEGYN 840
EVGPGYTPGE GASEQEKARG GYSSGFRDSV PIQGITLEEV SEIIGRDLSG FPARPGEEPP 900
A 901 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IDA:MGI.
 GO:0045333; P:cellular respiration; IDA:MGI.
 GO:0071285; P:cellular response to lithium ion; IDA:MGI.
 GO:0034644; P:cellular response to UV; IGI:MGI.
 GO:0007507; P:heart development; IGI:MGI.
 GO:0055001; P:muscle cell development; IGI:MGI.
 GO:0001569; P:patterning of blood vessels; IGI:MGI.
 GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0051145; P:smooth muscle cell differentiation; IGI:MGI. 
Interpro
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set.
 IPR002909; IPT_TIG_rcpt.
 IPR008366; NFAT.
 IPR008967; p53-like_TF_DNA-bd.
 IPR011539; RHD. 
Pfam
 PF00554; RHD
 PF01833; TIG 
SMART
 SM00429; IPT 
PROSITE
 PS01204; REL_1
 PS50254; REL_2 
PRINTS
 PR01789; NUCFACTORATC.