CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003924
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysosome-associated membrane glycoprotein 1 
Protein Synonyms/Alias
 LAMP-1; Lysosome-associated membrane protein 1; 120 kDa lysosomal membrane glycoprotein; CD107 antigen-like family member A; LGP-120; Lysosomal membrane glycoprotein A; LGP-A; P2B; CD107a 
Gene Name
 Lamp1 
Gene Synonyms/Alias
 Lamp-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
145DIKADINKAYRCVSDacetylation[1, 2]
145DIKADINKAYRCVSDsuccinylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. 
Sequence Annotation
 REGION 25 188 First lumenal domain.
 REGION 189 218 Hinge.
 REGION 219 370 Second lumenal domain.
 CARBOHYD 31 31 N-linked (GlcNAc...) (Potential).
 CARBOHYD 52 52 N-linked (GlcNAc...) (Potential).
 CARBOHYD 58 58 N-linked (GlcNAc...) (Potential).
 CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
 CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...).
 CARBOHYD 101 101 N-linked (GlcNAc...).
 CARBOHYD 115 115 N-linked (GlcNAc...) (Potential).
 CARBOHYD 159 159 N-linked (GlcNAc...).
 CARBOHYD 177 177 N-linked (GlcNAc...).
 CARBOHYD 214 214 N-linked (GlcNAc...) (Potential).
 CARBOHYD 219 219 N-linked (GlcNAc...) (Potential).
 CARBOHYD 232 232 N-linked (GlcNAc...) (Potential).
 CARBOHYD 240 240 N-linked (GlcNAc...) (Potential).
 CARBOHYD 252 252 N-linked (GlcNAc...) (high mannose).
 CARBOHYD 282 282 N-linked (GlcNAc...) (Potential).
 CARBOHYD 296 296 N-linked (GlcNAc...) (Potential).
 CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
 DISULFID 35 74
 DISULFID 149 185
 DISULFID 222 259
 DISULFID 327 364  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Endosome; Glycoprotein; Lysosome; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 406 AA 
Protein Sequence
MAAPGARRPL LLLLLAGLAH GASALFEVKN NGTTCIMASF SASFLTTYET ANGSQIVNIS 60
LPASAEVLKN GSSCGKENVS DPSLTITFGR GYLLTLNFTK NTTRYSVQHM YFTYNLSDTE 120
HFPNAISKEI YTMDSTTDIK ADINKAYRCV SDIRVYMKNV TVVLRDATIQ AYLSSGNFSK 180
EETHCTQDGP SPTTGPPSPS PPLVPTNPTV SKYNVTGNNG TCLLASMALQ LNITYLKKDN 240
KTVTRAFNIS PNDTSSGSCG INLVTLKVEN KNRALELQFG MNASSSLFFL QGVRLNMTLP 300
DALVPTFSIS NHSLKALQAT VGNSYKCNTE EHIFVSKMLS LNVFSVQVQA FKVDSDRFGS 360
VEECVQDGNN MLIPIAVGGA LAGLVLIVLI AYLIGRKRSH AGYQTI 406 
Gene Ontology
 GO:0097208; C:alveolar lamellar body; IEA:Compara.
 GO:0044194; C:cytolytic granule; IDA:MGI.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0042470; C:melanosome; IDA:MGI.
 GO:0005771; C:multivesicular body; IDA:MGI.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0048102; P:autophagic cell death; IEA:Compara.
 GO:0006914; P:autophagy; IEA:Compara.
 GO:0007283; P:spermatogenesis; TAS:MGI. 
Interpro
 IPR018134; LAMP_CS.
 IPR002000; Lysosome-assoc_membr_glycop. 
Pfam
 PF01299; Lamp 
SMART
  
PROSITE
 PS00310; LAMP_1
 PS00311; LAMP_2
 PS51407; LAMP_3 
PRINTS
 PR00336; LYSASSOCTDMP.