UniProt Accession

 RPOS_ECOLI; P13445; Q2MA88; Q79EB7 

Genbank Protein ID

 X16400; D13548; Z14969; U29579; U00096; AP009048; D17549; L07869 

Genbank Nucleotide ID

 CAA34435.1; BAA02747.1; CAA78692.1; AAA69251.1; AAC75783.1; BAE76818.1; BAA21003.1; AAA17876.1 

Protein Name

 RNA polymerase sigma factor RpoS 

Protein Synonyms/Alias

 Sigma S; Sigma-38 

Gene Name

 rpoS 

Gene Synonyms/Alias

 appR; katF; nur; otsX; sigS; b2741; JW5437 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
204	EIAEQLDKPVDDVSR	acetylation	[1]
232	PLGGDSEKALLDILA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management. 

Sequence Annotation

 DNA_BIND 288 307 H-T-H motif (By similarity).
 REGION 56 89 Sigma-70 factor domain-1.
 REGION 94 164 Sigma-70 factor domain-2.
 REGION 174 249 Sigma-70 factor domain-3.
 REGION 262 315 Sigma-70 factor domain-4.
 MOTIF 118 121 Interaction with polymerase core subunit  

Keyword

 Complete proteome; Cytoplasm; DNA-binding; Reference proteome; Sigma factor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 330 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:EcoCyc.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
 GO:0001123; P:transcription initiation from bacterial-type RNA polymerase promoter; IDA:EcoCyc. 

Interpro

 IPR014284; RNA_pol_sigma-70_dom.
 IPR000943; RNA_pol_sigma70.
 IPR009042; RNA_pol_sigma70_r1_2.
 IPR007627; RNA_pol_sigma70_r2.
 IPR007624; RNA_pol_sigma70_r3.
 IPR007630; RNA_pol_sigma70_r4.
 IPR013325; RNA_pol_sigma_r2.
 IPR013324; RNA_pol_sigma_r3_r4.
 IPR012761; RNA_pol_sigma_RpoS_proteobac.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00140; Sigma70_r1_2
 PF04542; Sigma70_r2
 PF04539; Sigma70_r3
 PF04545; Sigma70_r4 

SMART

  

PROSITE

 PS00715; SIGMA70_1
 PS00716; SIGMA70_2 

PRINTS

 PR00046; SIGMA70FCT.