UniProt Accession

 SRP14_YEAST; P38985; D6VRQ6 

Genbank Protein ID

 L35155; X95644; Z74140; Z74139; AY558159; BK006938 

Genbank Nucleotide ID

 AAA53402.1; CAA64919.1; CAA98659.1; CAA98658.1; AAS56485.1; DAA11766.1 

Protein Name

 Signal recognition particle subunit SRP14 

Protein Synonyms/Alias

 Signal recognition particle 14 kDa protein homolog 

Gene Name

 SRP14 

Gene Synonyms/Alias

 YDL092W; D2404 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
26	FFQTANEKHITVRLT	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP14 binds scR1 RNA to form the probable Alu domain of SRP responsible for elongation arrest. 

Sequence Annotation

 MOD_RES 8 8 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IDA:SGD.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
 GO:0005048; F:signal sequence binding; IPI:SGD.
 GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IC:SGD. 

Interpro

 IPR003210; Signal_recog_particle_SRP14.
 IPR009018; Signal_recog_particle_SRP9/14. 

Pfam

 PF02290; SRP14 

SMART

  

PROSITE

  

PRINTS