CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001445
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thioredoxin reductase 1, cytoplasmic 
Protein Synonyms/Alias
 TR; NADPH-dependent thioredoxin reductase; Thioredoxin reductase TR1 
Gene Name
 Txnrd1 
Gene Synonyms/Alias
 Trxr1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
33AAAKEAAKFDKKVMVacetylation[1]
133VYENAYGKFIGPHKIacetylation[1]
139GKFIGPHKIMATNNKacetylation[1]
150TNNKGKEKVYSAERFacetylation[1]
308GLETVGVKINEKTGKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 NP_BIND 42 59 FAD (By similarity).
 ACT_SITE 472 472 Proton acceptor.
 MOD_RES 131 131 Phosphotyrosine (By similarity).
 DISULFID 59 64 Redox-active.
 CROSSLNK 497 498 Cysteinyl-selenocysteine (Cys-Sec).  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; FAD; Flavoprotein; NADP; Oxidoreductase; Phosphoprotein; Redox-active center; Reference proteome; Selenocysteine. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 499 AA 
Protein Sequence
MNDSKDAPKS YDFDLIIIGG GSGGLAAAKE AAKFDKKVMV LDFVTPTPLG TRWGLGGTCV 60
NVGCIPKKLM HQAALLGQAL KDSRNYGWKL EDTVKHDWEK MTESVQNHIG SLNWGYRVAL 120
REKKVVYENA YGKFIGPHKI MATNNKGKEK VYSAERFLIA TGERPRYLGI PGDKEYCISS 180
DDLFSLPYCP GKTLVVGASY VALECAGFLA GIGLDVTVMV RSILLRGFDQ DMANKIGEHM 240
EEHGIKFIRQ FVPTKIEQIE AGTPGRLKVT AKSTNSEETI EDEFNTVLLA VGRDSCTRTI 300
GLETVGVKIN EKTGKIPVTD EEQTNVPYIY AIGDILEGKL ELTPVAIQAG RLLAQRLYGG 360
STVKCDYDNV PTTVFTPLEY GCCGLSEEKA VEKFGEENIE VYHSFFWPLE WTVPSRDNNK 420
CYAKVICNLK DNERVVGFHV LGPNAGEVTQ GFAAALKCGL TKQQLDSTIG IHPVCAEIFT 480
TLSVTKRSGG DILQSGCUG 499 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0045340; F:mercury ion binding; IDA:RGD.
 GO:0016174; F:NAD(P)H oxidase activity; IDA:RGD.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0033797; F:selenate reductase activity; IDA:RGD.
 GO:0004791; F:thioredoxin-disulfide reductase activity; IDA:RGD.
 GO:0042537; P:benzene-containing compound metabolic process; IDA:RGD.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0071280; P:cellular response to copper ion; IEP:RGD.
 GO:0071455; P:cellular response to hyperoxia; IEP:RGD.
 GO:0006749; P:glutathione metabolic process; IEP:RGD.
 GO:0070276; P:halogen metabolic process; IEP:RGD.
 GO:0042744; P:hydrogen peroxide catabolic process; IMP:RGD.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0042191; P:methylmercury metabolic process; IEP:RGD.
 GO:0070995; P:NADPH oxidation; IDA:RGD.
 GO:0001890; P:placenta development; IEP:RGD.
 GO:0010942; P:positive regulation of cell death; IMP:RGD.
 GO:0051262; P:protein tetramerization; IDA:RGD.
 GO:0048678; P:response to axon injury; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0010269; P:response to selenium ion; IEP:RGD.
 GO:0016259; P:selenocysteine metabolic process; IMP:RGD. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR006338; Thioredoxin/glutathione_Rdtase. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.