UniProt Accession

 TIM14_HUMAN; Q96DA6; B2R4B1; C9JBV1 

Genbank Protein ID

 AK311765; AC008009; CH471052; CH471052; CH471052; BC073989; BC009702 

Genbank Nucleotide ID

 BAG34708.1; EAW78358.1; EAW78360.1; EAW78362.1; AAH73989.1; AAH09702.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit TIM14 

Protein Synonyms/Alias

 DnaJ homolog subfamily C member 19 

Gene Name

 DNAJC19 

Gene Synonyms/Alias

 TIM14; TIMM14 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
34	KHMEPQVKQVFQSLP	ubiquitination	[1, 2]
42	QVFQSLPKSAFSGGY	ubiquitination	[1, 2]
93	MLLNHPDKGGSPYIA	acetylation	[3, 4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). 

Sequence Annotation

 DOMAIN 62 116 J.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 70 70 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Cardiomyopathy; Chaperone; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 116 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0048806; P:genitalia development; IMP:UniProtKB.
 GO:0006457; P:protein folding; NAS:UniProtKB.
 GO:0006626; P:protein targeting to mitochondrion; NAS:UniProtKB.
 GO:0007601; P:visual perception; IMP:UniProtKB. 

Interpro

 IPR001623; DnaJ_domain. 

Pfam

 PF00226; DnaJ 

SMART

 SM00271; DnaJ 

PROSITE

 PS00636; DNAJ_1
 PS50076; DNAJ_2 

PRINTS