CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009427
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calmodulin 
Protein Synonyms/Alias
 CaM 
Gene Name
 Cam 
Gene Synonyms/Alias
 CG8472 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
22EAFSLFDKDGDGTITacetylation[1]
31GDGTITTKELGTVMRacetylation[1]
95EAFRVFDKDGNGFISacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. 
Sequence Annotation
 DOMAIN 8 43 EF-hand 1.
 DOMAIN 44 79 EF-hand 2.
 DOMAIN 81 116 EF-hand 3.
 DOMAIN 117 149 EF-hand 4.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 95 95 N6,N6,N6-trimethyllysine.  
Keyword
 3D-structure; Acetylation; Calcium; Complete proteome; Metal-binding; Methylation; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 149 AA 
Protein Sequence
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 60
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGF ISAAELRHVM TNLGEKLTDE 120
EVDEMIREAD IDGDGQVNYE EFVTMMTSK 149 
Gene Ontology
 GO:0005814; C:centriole; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0030496; C:midbody; IDA:FlyBase.
 GO:0031475; C:myosin V complex; IPI:FlyBase.
 GO:0031476; C:myosin VI complex; IPI:FlyBase.
 GO:0016028; C:rhabdomere; IDA:FlyBase.
 GO:0000922; C:spindle pole; IDA:FlyBase.
 GO:0005509; F:calcium ion binding; IDA:FlyBase.
 GO:0005516; F:calmodulin binding; IDA:FlyBase.
 GO:0030048; P:actin filament-based movement; IDA:FlyBase.
 GO:0016062; P:adaptation of rhodopsin mediated signaling; TAS:FlyBase.
 GO:0007099; P:centriole replication; IMP:FlyBase.
 GO:0051383; P:kinetochore organization; IMP:FlyBase.
 GO:0046331; P:lateral inhibition; IMP:FlyBase.
 GO:0016060; P:metarhodopsin inactivation; IGI:FlyBase.
 GO:0007052; P:mitotic spindle organization; IMP:FlyBase.
 GO:0046716; P:muscle cell homeostasis; IGI:FlyBase.
 GO:0072499; P:photoreceptor cell axon guidance; IMP:FlyBase.
 GO:0051533; P:positive regulation of NFAT protein import into nucleus; IMP:FlyBase.
 GO:0006468; P:protein phosphorylation; IMP:FlyBase.
 GO:0016061; P:regulation of light-activated channel activity; IMP:FlyBase.
 GO:2001020; P:regulation of response to DNA damage stimulus; IGI:FlyBase.
 GO:0042052; P:rhabdomere development; IMP:FlyBase.
 GO:0007605; P:sensory perception of sound; IMP:FlyBase. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF13499; EF_hand_5 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS