UniProt Accession

 E9PDN7_HUMAN; E9PDN7 

Genbank Protein ID

 AC005018 

Genbank Nucleotide ID

  

Protein Name

 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 

Protein Synonyms/Alias

  

Gene Name

 PIK3CG 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	VPYDPGLKAGALAIE	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:Compara.
 GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0097284; P:hepatocyte apoptotic process; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0010897; P:negative regulation of triglyceride catabolic process; IEA:Compara.
 GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
 GO:0002675; P:positive regulation of acute inflammatory response; IEA:Compara.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0032252; P:secretory granule localization; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR015433; PI_Kinase. 

Pfam

 PF00454; PI3_PI4_kinase 

SMART

  

PROSITE

 PS00915; PI3_4_KINASE_1
 PS50290; PI3_4_KINASE_3 

PRINTS