UniProt Accession

 ARG39_HUMAN; Q8N4T4; Q49AG0; Q6TPQ2; Q96ST6 

Genbank Protein ID

 AY390225; AY390226; AL357874; BC033666; BC038673; AK027548 

Genbank Nucleotide ID

 AAR01010.1; AAR01011.1; CAI13452.1; AAH33666.1; BAB55192.1 

Protein Name

 Rho guanine nucleotide exchange factor 39 

Protein Synonyms/Alias

  

Gene Name

 ARHGEF39 

Gene Synonyms/Alias

 C9orf100 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
122	TTLQEQLKKNKGFRR	ubiquitination	[1, 2]
275	RSGTFACKALYPMAQ	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Promotes cell proliferation. 

Sequence Annotation

 DOMAIN 22 197 DH.
 DOMAIN 227 331 PH.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Guanine-nucleotide releasing factor; Membrane; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 

Interpro

 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 

Pfam

 PF00621; RhoGEF 

SMART

 SM00233; PH
 SM00325; RhoGEF 

PROSITE

 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN 

PRINTS