CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029522
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ras-related protein Rab-34, isoform NARR 
Protein Synonyms/Alias
  
Gene Name
 RAB34 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
169LFLVGSKKDLSTPAQubiquitination[1, 2]
192LQVAQEMKAEYWAVSubiquitination[3]
228NVLAELEKSGARRIGubiquitination[3]
253NLYLTASKKKPTCCPubiquitination[1, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 260 AA 
Protein Sequence
MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGR FKISKVIVVG 60
DLSVGKTCLI NRFCKDTFDK NYKATIGVDF EMERFEVLGI PFSLQLWDTA GQERFKCIAS 120
TYYRGAQAII IVFNLNDVAS LEHTKQWLAD ALKENDPSSV LLFLVGSKKD LSTPAQYALM 180
EKDALQVAQE MKAEYWAVSS LTGENVREFF FRVAALTFEA NVLAELEKSG ARRIGDVVRI 240
NSDDSNLYLT ASKKKPTCCP 260 
Gene Ontology
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
  
PRINTS
 PR00449; RASTRNSFRMNG.