UniProt Accession

 ENSA_MOUSE; P60840; Q5D069; Q6PBG4; Q9CQZ9; Q9Z0G1 

Genbank Protein ID

 AJ005985; AK006149; AK011334; AK149726; AK161290; AK019170; CH466620; BC058802; BC059724 

Genbank Nucleotide ID

 CAA06799.1; BAB24433.1; BAB27552.1; BAE29049.1; BAE36298.1; BAB31584.1; EDL38827.1; AAH58802.1; AAH59724.1 

Protein Name

 Alpha-endosulfine 

Protein Synonyms/Alias

 ARPP-19e 

Gene Name

 Ensa 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
63	KRLQKGQKYFDSGDY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 67 67 Phosphoserine; by GWL (Probable).
 MOD_RES 108 108 Phosphoserine; by PKA (By similarity).
 MOD_RES 109 109 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Mitosis; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 121 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0019212; F:phosphatase inhibitor activity; ISS:UniProtKB.
 GO:0051721; F:protein phosphatase 2A binding; ISS:UniProtKB.
 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0008601; F:protein phosphatase type 2A regulator activity; ISS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB.
 GO:0007067; P:mitosis; ISS:UniProtKB.
 GO:0009749; P:response to glucose stimulus; IEA:Compara. 

Interpro

 IPR006760; Endosulphine. 

Pfam

 PF04667; Endosulfine 

SMART

  

PROSITE

  

PRINTS