CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041282
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lin-7 homolog C (C. elegans), isoform CRA_b 
Protein Synonyms/Alias
 Protein lin-7 homolog C 
Gene Name
 LIN7C 
Gene Synonyms/Alias
 hCG_27394 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23RAIELLEKLQRSGEVubiquitination[1, 2, 3, 4]
34SGEVPPQKLQALQRVubiquitination[1]
87GFNIMGGKEQNSPIYubiquitination[3]
137EKAVELLKAAQGKVKubiquitination[2, 4]
152LVVRYTPKVLEEMESubiquitination[1, 3, 4, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 173 AA 
Protein Sequence
MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV REATVAAFAA 60
SEGHSHPRVV ELPKTEEGLG FNIMGGKEQN SPIYISRIIP GGIADRHGGL KRGDQLLSVN 120
GVSVEGEHHE KAVELLKAAQ GKVKLVVRYT PKVLEEMESR FEKMRSAKRR QQT 173 
Gene Ontology
  
Interpro
 IPR004172; L27.
 IPR014775; L27_C.
 IPR001478; PDZ. 
Pfam
 PF02828; L27
 PF00595; PDZ 
SMART
 SM00569; L27
 SM00228; PDZ 
PROSITE
 PS51022; L27
 PS50106; PDZ 
PRINTS