CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022518
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium-binding and coiled-coil domain-containing protein 1 
Protein Synonyms/Alias
 Calphoglin; Coiled-coil coactivator protein; Sarcoma antigen NY-SAR-3 
Gene Name
 CALCOCO1 
Gene Synonyms/Alias
 KIAA1536; PP13275; UNQ2436/PRO4996 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29RTYIPNTKVECHYTLsumoylation[1]
Reference
 [1] Differential regulation of the two transcriptional activation domains of the coiled-coil coactivator CoCoA by sumoylation.
 Yang CK, Kim JH, Ann DK, Stallcup MR.
 BMC Mol Biol. 2008 Jan 25;9:12. [PMID: 18218142] 
Functional Description
 Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). 
Sequence Annotation
 REGION 1 190 N-terminal AD (CTNNB1 binding site) (By
 REGION 1 30 p300 KIX-binding (By similarity).
 REGION 501 691 C-terminal AD (CTNNB1 binding site) (By
 MOD_RES 563 563 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 691 AA 
Protein Sequence
MEESPLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT MPSASDWIGI FKVEAACVRD 60
YHTFVWSSVP ESTTDGSPIH TSVQFQASYL PKPGAQLYQF RYVNRQGQVC GQSPPFQFRE 120
PRPMDELVTL EEADGGSDIL LVVPKATVLQ NQLDESQQER NDLMQLKLQL EGQVTELRSR 180
VQELERALAT ARQEHTELME QYKGISRSHG EITEERDILS RQQGDHVARI LELEDDIQTI 240
SEKVLTKEVE LDRLRDTVKA LTREQEKLLG QLKEVQADKE QSEAELQVAQ QENHHLNLDL 300
KEAKSWQEEQ SAQAQRLKDK VAQMKDTLGQ AQQRVAELEP LKEQLRGAQE LAASSQQKAT 360
LLGEELASAA AARDRTIAEL HRSRLEVAEV NGRLAELGLH LKEEKCQWSK ERAGLLQSVE 420
AEKDKILKLS AEILRLEKAV QEERTQNQVF KTELAREKDS SLVQLSESKR ELTELRSALR 480
VLQKEKEQLQ EEKQELLEYM RKLEARLEKV ADEKWNEDAT TEDEEAAVGL SCPAALTDSE 540
DESPEDMRLP PYGLCERGDP GSSPAGPREA SPLVVISQPA PISPHLSGPA EDSSSDSEAE 600
DEKSVLMAAV QSGGEEANLL LPELGSAFYD MASGFTVGTL SETSTGGPAT PTWKECPICK 660
ERFPAESDKD ALEDHMDGHF FFSTQDPFTF E 691 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0005634; C:nucleus; IDA:LIFEdb.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IDA:AgBase.
 GO:0043565; F:sequence-specific DNA binding; IDA:AgBase.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0030518; P:intracellular steroid hormone receptor signaling pathway; ISS:HGNC.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; ISS:HGNC.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR012852; CoCoA. 
Pfam
 PF07888; CALCOCO1 
SMART
  
PROSITE
  
PRINTS