CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 26A1 
Protein Synonyms/Alias
 Cytochrome P450RAI; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome 
Gene Name
 Cyp26a1 
Gene Synonyms/Alias
 Cyp26; P450ra 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
338KSKGLLCKSNQDNKLubiquitination[1]
344CKSNQDNKLDMETLEubiquitination[1]
379GGFRVALKTFELNGYubiquitination[1]
475LNGPPTMKTSPTVYPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. 
Sequence Annotation
 METAL 442 442 Iron (heme axial ligand) (Potential).  
Keyword
 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 497 AA 
Protein Sequence
MGLPALLASA LCTFVLPLLL FLAALKLWDL YCVSSRDRSC ALPLPPGTMG FPFFGETLQM 60
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL 120
GAGCLSNLHD SSHKQRKKVI MQAFSREALQ CYVLVIAEEV SSCLEQWLSC GERGLLVYPE 180
VKRLMFRIAM RILLGCEPGP AGGGEDEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGVKAR 240
NLIHARIEEN IRAKIRRLQA TEPDGGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG 300
GHETTASAAT SLITYLGLYP HVLQKVREEI KSKGLLCKSN QDNKLDMETL EQLKYIGCVI 360
KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVADIFTN KEEFNPDRFI 420
VPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV 480
YPVDNLPARF TYFQGDI 497 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0008401; F:retinoic acid 4-hydroxylase activity; IEA:Compara.
 GO:0001972; F:retinoic acid binding; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0071300; P:cellular response to retinoic acid; IEP:UniProtKB.
 GO:0007417; P:central nervous system development; IMP:MGI.
 GO:0014032; P:neural crest cell development; IGI:MGI.
 GO:0034653; P:retinoic acid catabolic process; ISA:MGI.
 GO:0048384; P:retinoic acid receptor signaling pathway; IGI:MGI. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002403; Cyt_P450_E_grp-IV. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00465; EP450IV.
 PR00385; P450.