| Tag | Content |
|---|
| CPLM ID | CPLM-001157 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 217 |
Protein Synonyms/Alias | |
Gene Name | ZNF217 |
Gene Synonyms/Alias | ZABC1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 918 | EFGEPLPKRLKSSVV | ubiquitination | [1] | | 921 | EPLPKRLKSSVVALD | ubiquitination | [1] |
|
Reference | [1] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] |
Functional Description | Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. |
Sequence Annotation | ZN_FING 65 88 C2H2-type 1.
ZN_FING 128 150 C2H2-type 2.
ZN_FING 156 178 C2H2-type 3.
ZN_FING 216 238 C2H2-type 4.
ZN_FING 375 397 C2H2-type 5.
ZN_FING 471 493 C2H2-type 6.
ZN_FING 499 521 C2H2-type 7.
MOD_RES 321 321 Phosphoserine.
MOD_RES 322 322 Phosphothreonine.
MOD_RES 407 407 Phosphoserine.
MOD_RES 648 648 Phosphothreonine.
MOD_RES 662 662 Phosphoserine.
MOD_RES 795 795 Phosphoserine. |
Keyword | 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1048 AA |
Protein Sequence | MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA TQEKNVIQIE 60
GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV EAEYLSPLDK SQVRTEPPKE 120
KNCKENEFSC EVCGQTFRVA FDVEIHMRTH KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG 180
KSGARSKLQQ GLESSPATIN EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK 240
KTAFGTSSAQ TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ 300
LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK CKHSHGEAPS 360
VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD RRAGAESPTM SVDGRQPGTC 420
SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP EGIHLDKNDD GGKIKHLTSS RECSYCGKFF 480
RSNYYLNIHL RTHTGEKPYK CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ 540
DTEDALLTAD SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ 600
DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP PDGSTTHNLE 660
VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI SLSKSLIPSI TCPFCTFKTF 720
YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF 780
PAQSKSLPSA KGKQSPPGPG KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE 840
MFPKTSVSPA PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF 900
CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG ITSLLPQDCV 960
YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV PAGSPASSST LEGKRPVSYQ 1020
HLSNSMAQKR NYENFIGNAH YRPNDKKT 1048 |
Gene Ontology | GO:0000118; C:histone deacetylase complex; IDA:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |