CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029095
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disintegrin and metalloproteinase domain-containing protein 15 
Protein Synonyms/Alias
  
Gene Name
 ADAM15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58DDLPISLKKVLQTSLubiquitination[1, 2, 3, 4]
59DLPISLKKVLQTSLPubiquitination[1, 3]
106CSRRALEKALLDGMGubiquitination[3]
366GAQECRSKCHGHGVCubiquitination[1]
435HQRLCQLKGPTCQYRubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 520 AA 
Protein Sequence
MRLALLWALG LLGAGSPLPS WPLPNIGGTE EQQAESEKAP REPLEPQVLQ DDLPISLKKV 60
LQTSLPEPLR IKLELDGDSH ILELLQNRSF LPGLNFSNCS RRALEKALLD GMGSCLFERL 120
PSLPPMAAFC GNMFVEPGEQ CDCGFLDDCV DPCCDSLTCQ LRPGAQCASD GPCCQNCQLR 180
PSGWQCRPTR GDCDLPEFCP GDSSQCPPDV SLGDGEPCAG GQAVCMHGRC ASYAQQCQSL 240
WGPGAQPAAP LCLQTANTRG NAFGSCGRNP SGSYVSCTPR DAICGQLQCQ TGRTQPLLGS 300
IRDLLWETID VNGTELNCSW VHLDLGSDVA QPLLTLPGTA CGPGLVCIDH RCQRVDLLGA 360
QECRSKCHGH GVCDSNRHCY CEEGWAPPDC TTQLKATSSL TTGLLLSLLV LLVLVMLGAS 420
YWYRARLHQR LCQLKGPTCQ YRAAQSGPSE RPGPPQRALL ARGTKSQGPA KPPPPRKPLP 480
ADPQGRCPSG DLPGPGAGIP PLVVPSRPAP PPPTVSSLYL 520 
Gene Ontology
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR006586; ADAM_Cys-rich.
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR024079; MetalloPept_cat_dom. 
Pfam
 PF08516; ADAM_CR
 PF00200; Disintegrin 
SMART
 SM00608; ACR
 SM00050; DISIN
 SM00181; EGF 
PROSITE
 PS50214; DISINTEGRIN_2
 PS01186; EGF_2
 PS50026; EGF_3 
PRINTS