UniProt Accession

 AP3M1_HUMAN; Q9Y2T2; Q5JQ12; Q9H5L2 

Genbank Protein ID

 AF092092; AK026983; AL731576; BC026232; BC067127 

Genbank Nucleotide ID

 AAD20446.1; BAB15614.1; CAI39670.1; AAH26232.1; AAH67127.1 

Protein Name

 AP-3 complex subunit mu-1 

Protein Synonyms/Alias

 AP-3 adapter complex mu3A subunit; Adapter-related protein complex 3 mu-1 subunit; Mu-adaptin 3A; Mu3A-adaptin 

Gene Name

 AP3M1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
135	NILKELIKPPTILRS	ubiquitination	[1]
283	VKHSISFKENSSCGR	ubiquitination	[2, 3]
398	RLDMYGEKYKPFKGV	ubiquitination	[4]
400	DMYGEKYKPFKGVKY	ubiquitination	[4]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. 

Sequence Annotation

 DOMAIN 176 417 MHD.  

Keyword

 Complete proteome; Golgi apparatus; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; TAS:ProtInc.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0006622; P:protein targeting to lysosome; TAS:ProtInc. 

Interpro

 IPR022775; AP_mu_sigma_su.
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS.
 IPR011012; Longin-like_dom. 

Pfam

 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS00990; CLAT_ADAPTOR_M_1
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 

PRINTS

 PR00314; CLATHRINADPT.