CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019551
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 237 
Protein Synonyms/Alias
 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein 
Gene Name
 TMEM237 
Gene Synonyms/Alias
 ALS2CR4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
92LETSSTQKKSSSSSLubiquitination[1]
118AEEAVIQKPRRKTKKubiquitination[1]
201IDVSMDVKPSWTTRDubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Component of the transition zone in primary cilia. Required for ciliogenesis. 
Sequence Annotation
  
Keyword
 Alternative splicing; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Complete proteome; Joubert syndrome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 408 AA 
Protein Sequence
MGKNPVRPPR ALPPVPSQDD IPLSRPKKKK PRTKNTPASA SLEGLAQTAG RRPSEGNEPS 60
TKELKEHPEA PVQRRQKKTR LPLELETSST QKKSSSSSLL RNENGIDAEP AEEAVIQKPR 120
RKTKKTQPAE LQYANELGVE DEDIITDEQT TVEQQSVFTA PTGISQPVGK VFVEKSRRFQ 180
AADRSELIKT TENIDVSMDV KPSWTTRDVA LTVHRAFRMI GLFSHGFLAG CAVWNIVVIY 240
VLAGDQLSNL SNLLQQYKTL AYPFQSLLYL LLALSTISAF DRIDFAKISV AIRNFLALDP 300
TALASFLYFT ALILSLSQQM TSDRIHLYTP SSVNGSLWEA GIEEQILQPW IVVNLVVALL 360
VGLSWLFLSY RPGMDLSEEL MFSSEVEEYP DKEKEIKASS 400 
Gene Ontology
 GO:0035869; C:ciliary transition zone; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042384; P:cilium assembly; IMP:UniProtKB.
 GO:0030111; P:regulation of Wnt receptor signaling pathway; IMP:UniProtKB. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS