CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029157
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alstrom syndrome protein 1 
Protein Synonyms/Alias
 Uncharacterized protein 
Gene Name
 ALMS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
349LCSYMSWKTRKDTQWubiquitination[1]
896VPGPGDQKTGIPSAPubiquitination[2]
912SFYSHREKPIIFSQQubiquitination[2]
979DLPRESLKMSAIPGLubiquitination[2]
1027YATEKALKVSTGPGPubiquitination[1]
1622GSSALGEKPITFYRQacetylation[3]
1669TSYSNRGKPVIFYQQacetylation[4]
1716SLYSYREKPIVFYQQubiquitination[2]
1839VPGPADQKTGINILPubiquitination[2]
1929VPGQGDRKTEIPTVPubiquitination[2]
2052SSYSQTVKPNILFQQubiquitination[2]
2086LTDVNTGKPVSLSSSubiquitination[2]
2099SSYFHREKSNIFSPQubiquitination[2]
2130IPGPAGQKTVLPTALubiquitination[2]
2146SSFSHREKPDIFYQKubiquitination[2]
2153KPDIFYQKDLPDRHLubiquitination[2]
2195YSHGENHKLVSEHVQubiquitination[5]
2234DDRVVINKPESAGFRubiquitination[3]
2256QDAENSAKTLKEIRTubiquitination[2]
2274EAENMALKRCNFPAPubiquitination[1, 2, 3, 6]
2297DISFIQSKKVVCFKEubiquitination[2]
2298ISFIQSKKVVCFKEPubiquitination[2]
2333PSSRCIQKDIGTQTNubiquitination[2]
2342IGTQTNLKCRRGIENubiquitination[2]
2368PLQEAESKVSMALEEubiquitination[2]
2384LRQYQAAKSVMRSEPubiquitination[2]
2401CSGTIGNKIIIPMMTubiquitination[2]
2496ESSLNHAKEILRNAEubiquitination[2, 3]
2538LNEDDRRKVEEIKAEubiquitination[2]
2543RRKVEEIKAELFGHGubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2561 AA 
Protein Sequence
MEPEDLPWPG ELEEEEEEEE EEEEEEEEAA AAAAANVDDV VVVEEVEEEA GRELDSDSHY 60
GPQHLESIDD EEDEEAKAWL QAHPGRILPP LSPPQHRYSE GERTSLEKIV PLTCHVWQQI 120
VYQGNSRTQI SDTNVVCLET TAQRGSGDDQ KTESWHCLPQ EMDSSQTLDT SQTRFNVRTE 180
DTEVTDFPSL EEGILTQSEN QVKEPNRDLF CSPLLVIQDS FASPDLPLLT CLTQDQEFAP 240
DSLFHQSELS FAPLRGIPDK SEDTEWSSRP SEVSEALFQA TAEVASDLAS SRFSVSQHPL 300
IGSTAVGSQC PFLPSEQGNN EETISSVDEL KIPKDCDRYD DLCSYMSWKT RKDTQWPENN 360
LADKDQVSVA TSFDITDENI ATKRSDHFDA ARSYGQYWTQ EDSSKQAETY LTKGLQGKVE 420
SDVITLDGLN ENAVVCSERV AELQRKPTRE SEYHSSDLRM LRMSPDTVPK APKHLKAGDT 480
SKGGIAKVTQ SNLKSGITTT PVDSDIGSHL SLSLEDLSQL AVSSLETTTG QHTDTLNQKT 540
LADTHLTEET LKVTAIPEPA DQKTATPTVL SSSHSHRGKP SIFYQQGLPD SHLTEEALKV 600
SAAPGLADQT TGMSTLTSTS YSHREKPGTF YQQELPESNL TEEPLEVSAA PGPVEQKTGI 660
PTVSSTSHSH VEDLLFFYRQ TLPDGHLTDQ ALKVSAVSGP ADQKTGTATV LSTPHSHREK 720
PGIFYQQEFA DSHQTEETLT KVSATPGPAD QKTEIPAVQS SSYSQREKPS ILYPQDLADS 780
HLPEEGLKVS AVAGPADQKT GLPTVPSSAY SHREKLLVFY QQALLDSHLP EEALKVSAVS 840
GPADGKTGTP AVTSTSSASS SLGEKPSAFY QQTLPNSHLT EEALKVSIVP GPGDQKTGIP 900
SAPSSFYSHR EKPIIFSQQT LPDFLFPEEA LKVSAVSVLA AQKTGTPTVS SNSHSHSEKS 960
SVFYQQELPD SDLPRESLKM SAIPGLTDQK TVPTPTVPSG SFSHREKPSI FYQQEWPDSY 1020
ATEKALKVST GPGPADQKTE IPAVQSSSYP QREKPSVLYP QVLSDSHLPE ESLKVSAFPG 1080
PADQMTDTPA VPSTFYSQRE KPGIFYQQTL PESHLPKEAL KISVAPGLAD QKTGTPTVTS 1140
TSYSQHREKP SIFHQQALPG THIPEEAQKV SAVTGPGNQK TWIPRVLSTF YSQREKPGIF 1200
YQQTLPGSHI PEEAQKVSPV LGPADQKTGT PTPTSASYSH TEKPGIFYQQ VLPDNHPTEE 1260
ALKISVASEP VDQTTGTPAV TSTSYSQYRE KPSIFYQQSL PSSHLTEEAK NVSAVPGPAD 1320
QKTVIPILPS TFYSHTEKPG VFYQQVLPHS HPTEEALKIS VASEPVDQTT GTPTVTSTSY 1380
SQHTEKPSIF YQQSLPGSHL TEEAKNVSAV PGPGDRKTGI PTLPSTFYSH TEKPGSFYQQ 1440
VLPHSHLPEE ALEVSVAPGP VDQTIGTPTV TSPSSSFGEK PIVIYKQAFP EGHLPEESLK 1500
VSVAPGPVGQ TTGAPTITSP SYSQHRAKSG SFYQLALLGS QIPEEALRVS SAPGPADQTT 1560
GIPTITSTSY SFGEKPIVNY KQAFPDGHLP EEALKVSIVS GPTEKKTDIP AGPLGSSALG 1620
EKPITFYRQA LLDSPLNKEV VKVSAAPGPA DQKTETLPVH STSYSNRGKP VIFYQQTLSD 1680
SHLPEEALKV PPVPGPDAQK TETPSVSSSL YSYREKPIVF YQQALPDSEL TQEALKVSAV 1740
PQPADQKTGL STVTSSFYSH TEKPNISYQQ ELPDSHLTEE ALKVSNVPGP ADQKTGVSTV 1800
TSTSYSHREK PIVSYQRELP HFTEAGLKIL RVPGPADQKT GINILPSNSY PQREHSVISY 1860
EQELPDLTEV TLKAIGVPGP ADQKTGIQIA SSSSYSNREK ASIFHQQELP DVTEEALNVF 1920
VVPGQGDRKT EIPTVPLSYY SRREKPSVIS QQELPDSHLT EEALKVSPVS IPAEQKTGIP 1980
IGLSSSYSHS HKEKLKISTV HIPDDQKTEF PAATLSSYSQ IEKPKISTVI GPNDQKTPSQ 2040
TAFHSSYSQT VKPNILFQQQ LPDRDQSKGI LKISAVPELT DVNTGKPVSL SSSYFHREKS 2100
NIFSPQELPG SHVTEDVLKV STIPGPAGQK TVLPTALPSS FSHREKPDIF YQKDLPDRHL 2160
TEDALKISSA LGQADQITGL QTVPSGTYSH GENHKLVSEH VQRLIDNLNS SDSSVSSNNV 2220
LLNSQADDRV VINKPESAGF RDVGSEEIQD AENSAKTLKE IRTLLMEAEN MALKRCNFPA 2280
PLARFRDISD ISFIQSKKVV CFKEPSSTGV SNGDLLHRQP FTEESPSSRC IQKDIGTQTN 2340
LKCRRGIENW EFISSTTVRS PLQEAESKVS MALEETLRQY QAAKSVMRSE PEGCSGTIGN 2400
KIIIPMMTVI KSDSSSDASD GNGSCSWDSN LPESLESVSD VLLNFFPYVS PKTSITDSRE 2460
EEGVSESEDG GGSSVDSLAA HVKNLLQCES SLNHAKEILR NAEEEESRVR AHAWNMKFNL 2520
AHDCGYSISE LNEDDRRKVE EIKAELFGHG RTTDLSKGLQ S 2561 
Gene Ontology
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0019722; P:calcium-mediated signaling; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0050673; P:epithelial cell proliferation; IEA:Compara.
 GO:0001736; P:establishment of planar polarity; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0060122; P:inner ear receptor stereocilium organization; IEA:Compara.
 GO:0040015; P:negative regulation of multicellular organism growth; IEA:Compara.
 GO:0030728; P:ovulation; IEA:Compara.
 GO:0045598; P:regulation of fat cell differentiation; IEA:Compara.
 GO:0046548; P:retinal rod cell development; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0007286; P:spermatid development; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS