UniProt Accession

 DMA_HUMAN; P28067; Q29639; Q29640 

Genbank Protein ID

 X62744; AL935042; Z24753; U04878; U04877 

Genbank Nucleotide ID

 CAA44606.1; AAA56994.1; AAA56993.1 

Protein Name

 HLA class II histocompatibility antigen, DM alpha chain 

Protein Synonyms/Alias

 MHC class II antigen DMA; Really interesting new gene 6 protein 

Gene Name

 HLA-DMA 

Gene Synonyms/Alias

 DMA; RING6 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
119	IGPKLDGKIPVSRGF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. 

Sequence Annotation

 DOMAIN 121 215 Ig-like C1-type.
 REGION 27 124 Alpha-1.
 REGION 125 217 Alpha-2.
 REGION 218 233 Connecting peptide (Potential).
 CARBOHYD 41 41 N-linked (GlcNAc...) (Potential).
 DISULFID 50 105
 DISULFID 147 202  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Endosome; Glycoprotein; Immunity; Lysosome; Membrane; MHC II; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; TAS:Reactome.
 GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
 GO:0005771; C:multivesicular body; IEA:Compara.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0051085; P:chaperone mediated protein folding requiring cofactor; IEA:Compara.
 GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara.
 GO:0048839; P:inner ear development; IEA:Compara.
 GO:0050778; P:positive regulation of immune response; IEA:Compara.
 GO:0045582; P:positive regulation of T cell differentiation; IEA:Compara.
 GO:0045059; P:positive thymic T cell selection; IEA:Compara.
 GO:0006461; P:protein complex assembly; IEA:Compara.
 GO:0015031; P:protein transport; IEA:Compara. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR014745; MHC_II_a/b_N.
 IPR001003; MHC_II_a_N. 

Pfam

 PF07654; C1-set
 PF00993; MHC_II_alpha 

SMART

 SM00407; IGc1
 SM00920; MHC_II_alpha 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS