CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018923
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 P2X purinoceptor 5 
Protein Synonyms/Alias
 P2X5; ATP receptor; Purinergic receptor 
Gene Name
 P2RX5 
Gene Synonyms/Alias
 P2X5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
148VTAGNGVKTGRCLRRubiquitination[1]
193EDFTIFIKNHIRFPKubiquitination[1]
217VKDRSFLKSCHFGPKubiquitination[1]
286RLDNKLSKSVSSGYNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Receptor for ATP that acts as a ligand-gated ion channel. 
Sequence Annotation
 CARBOHYD 77 77 N-linked (GlcNAc...) (Potential).
 CARBOHYD 202 202 N-linked (GlcNAc...) (Potential).
 DISULFID 118 169 By similarity.
 DISULFID 129 152 By similarity.
 DISULFID 135 163 By similarity.
 DISULFID 220 229 By similarity.
 DISULFID 263 272 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 422 AA 
Protein Sequence
MGQAGCKGLC LSLFDYKTEK YVIAKNKKVG LLYRLLQASI LAYLVVWVFL IKKGYQDVDT 60
SLQSAVITKV KGVAFTNTSD LGQRIWDVAD YVIPAQGENV FFVVTNLIVT PNQRQNVCAE 120
NEGIPDGACS KDSDCHAGEA VTAGNGVKTG RCLRRENLAR GTCEIFAWCP LETSSRPEEP 180
FLKEAEDFTI FIKNHIRFPK FNFSNNVMDV KDRSFLKSCH FGPKNHYCPI FRLGSVIRWA 240
GSDFQDIALE GGVIGINIEW NCDLDKAASE CHPHYSFSRL DNKLSKSVSS GYNFRFARYY 300
RDAAGVEFRT LMKAYGIRFD VMVNGKGAFF CDLVLIYLIK KREFYRDKKY EEVRGLEDSS 360
QEAEDEASGL GLSEQLTSGP GLLGMPEQQE LQEPPEAKRG SSSQKGNGSV CPQLLEPHRS 420
T 421 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005524; F:ATP binding; NAS:BHF-UCL.
 GO:0004931; F:extracellular ATP-gated cation channel activity; NAS:BHF-UCL.
 GO:0001614; F:purinergic nucleotide receptor activity; NAS:BHF-UCL.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0010524; P:positive regulation of calcium ion transport into cytosol; NAS:BHF-UCL.
 GO:0050850; P:positive regulation of calcium-mediated signaling; NAS:BHF-UCL. 
Interpro
 IPR003048; P2X5_purnocptor.
 IPR027309; P2X_extracellular_dom.
 IPR001429; P2X_purnocptor. 
Pfam
 PF00864; P2X_receptor 
SMART
  
PROSITE
 PS01212; P2X_RECEPTOR 
PRINTS
 PR01312; P2X5RECEPTOR.
 PR01307; P2XRECEPTOR.