UniProt Accession

 CC103_HUMAN; Q8IW40; A8K145; B8ZZU0 

Genbank Protein ID

 AK289760; DA749894; AC015936; BC041060 

Genbank Nucleotide ID

 BAF82449.1; AAH41060.1 

Protein Name

 Coiled-coil domain-containing protein 103 

Protein Synonyms/Alias

  

Gene Name

 CCDC103 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	RNDIINFKALEKELQ	ubiquitination	[1]
14	INFKALEKELQAALT	ubiquitination	[1]
27	LTADEKYKRENAAKL	ubiquitination	[1]
94	ATEISPEKAPLQPET	ubiquitination	[1]
197	SCKGLFQKLQAMGNP	ubiquitination	[1]
208	MGNPRSVKEGLSWEE	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Dynein-attachment factor required for cilia motility. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Flagellum; Primary ciliary dyskinesia; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 242 AA 

Protein Sequence

Gene Ontology

 GO:0035085; C:cilium axoneme; ISS:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
 GO:0071907; P:determination of digestive tract left/right asymmetry; IMP:BHF-UCL.
 GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IC:BHF-UCL.
 GO:0001947; P:heart looping; IMP:BHF-UCL.
 GO:0036159; P:inner dynein arm assembly; IGI:BHF-UCL.
 GO:0036158; P:outer dynein arm assembly; IGI:BHF-UCL. 

Interpro

 IPR025986; RPAP3-like_C. 

Pfam

 PF13877; RPAP3_C 

SMART

  

PROSITE

  

PRINTS